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Modeling Cancer in Mice

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Katerina Politi, Yale School of Medicine; Corey Abate-Shen, Columbia University Irving Medical Center

Download a Free Excerpt from Modeling Cancer in Mice:

The Evolution of Mouse Models of Cancer: Past, Present, and Future

Due July 2024 • 338 pages, illustrated (59 color and 1 B&W), index
Hardcover •
ISBN  978-1-621824-72-5

  •     Description    
  •     Contents    


Mice are a useful model system for exploring how cancer develops, progresses, and may be treated. Studies of genetically engineered mouse models (GEMMs) and mice bearing patient-derived xenografts have yielded important insights into the biology of human cancer, and new technologies have moved the field forward significantly in the past decade.

Written and edited by experts in the field, this new volume from Cold Spring Harbor Perspectives in Medicine reviews the wide variety of mouse cancer models that have been developed and the ways in which they are improving our understanding of cancer and creating new therapeutic opportunities. The contributors discuss the various genetic techniques used to make mouse models and the plethora of GEMMs representing most common cancer types. They explain how our knowledge of the cell cycle, tumor metabolism, and cancer cell plasticity has benefited, as well as insights into the role of the microenvironment and the immune system.

The authors also examine more sophisticated models being leveraged to investigate drug responses and unpick phenomena like tumor dormancy. Other chapters cover technical advances, such as high-throughput studies, CRISPR genome engineering, and advanced imaging approaches that make it possible to track individual cancer cells. The book will therefore be of interest not only to cancer biologists but cell and developmental biologists interested in how cellular behavior can become deregulated in pathological conditions.


The Evolution of Mouse Models of Cancer: Past, Present, and Future
Cory Abate-Shen and Katerina Politi
Monitoring the Cell Cycle of Tumor Cells in Mouse Models of Human Cancer
Taylar Hammond and Julien Sage
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression
Melissa Q. Reeves and Allan Balmain
Cellular Origins and Lineage Plasticity in Cancer
Jason R. Pitarresi and Ben Z. Stanger
Mouse Models of Metastasis and Dormancy
Ahmed Mahmoud and Karuna Ganesh
Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses
Kathleen M. McAndrews, Krishnan K. Mahadevan, and Raghu Kalluri
Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse
Aria Vaishnavi, Conan G. Kinsey, and Martin McMahon
Advances in Studying Cancer Immunology in Mice
Marcus Bosenberg
Approaches to Study Tumor Metabolism in Mice
Yetis Gultekin, Matthew G. Vander Heiden, and Evan C. Lien
Advances in Making Cancer Mouse Models More Accessible and Informative through Non-Germline Genetic Engineering
Katherine C. Murphy and Marcus Ruscetti
How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research
Francisco J. Sánchez Rivera and Lukas E. Dow
High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo
Yuning J. Tang, Emily G. Shuldiner, Saswati Karmakar, and Monte M. Winslow
Next-Generation Modeling of Cancer Using Organoids
Jillian R. Love and Wouter R. Karthaus
Patient-Derived Xenografts in Mice: A Preclinical Platform for Cancer Research
Emiliano Cocco and Elisa de Stanchina
Imaging Approaches in Cancer Biology
Nirakar Rajbhandari, Emily Diaz, Marcie Kritzik, and Tannishtha Reya
Addressing Biological Questions with Preclinical Cancer Imaging
Chris B. Damoci, Joseph R. Merrill, Yanping Sun, Scott K. Lyons, and Kenneth P. Olive