Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities

Click to Enlarge				Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Cell Biology; Cancer Biology Edited by Navdeep S. Chandel, Northwestern University; Karen H. Vousden, The Francis Crick Institute; Ralph J. DeBerardinis, UT Southwestern Medical Center

				© 2025 • 430 pages, illustrated (84 color), index Hardcover • $79 ISBN 978-1-621824-70-1

Description Contents Description Cancer cells often display metabolic changes that distinguish them from normal calls in the body. Their preference for glycolysis over aerobic respiration even in the presence of oxygen was first observed over a century ago; however, it is only over the past two decades that researchers have begun to characterize all the pathways involved and investigate the therapeutic possibilities. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of the diversity of metabolic changes seen in cancer cells and their roles in sustaining tumor survival and proliferation. The contributors cover the new technologies being used to monitor metabolism in cells, the Warburg effect and the importance of mitochondria, metabolic signaling, and the importance of redox reactions and antioxidants. Other chapters examine the role of the tumor microenvironment, metal ions, and the immune system. The book also discusses the role of diet and how studies of patients are revealing how metabolic reprogramming occurs. It will thus be of interest not only to biochemists and oncologists but to all biologists interested in how the behavior of cells is regulated and coordinated. Contents Preface Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus Chi V. Dang Imaging Tumor Metabolism Thomas Ruan and Kayvan R. Keshari Technologies for Decoding Cancer Metabolism with Spatial Resolution Walter W. Chen, Michael E. Pacold, David M. Sabatini, and Naama Kanarek Oncogenic Control of Metabolism Natalya N. Pavlova and Craig B. Thompson Lessons Learned from Cancer Metabolism for Physiology and Disease Sydney L. Campbell and Heather R. Christofk Growth Signaling Networks Orchestrate Cancer Metabolic Networks Brendan D. Manning and Christian C. Dibble Metabolic Signaling in Cancer Laura V. Pinheiro, Pedro Costa-Pinheiro, and Kathryn E. Wellen Understanding the Warburg Effect in Cancer Zhaoqi Li, Muhammad Bin Munim, Daniel A. Sharygin, Brooke J. Bevis, and Matthew G. Vander Heiden Mitochondria and Cancer Timothy C. Kenny and Kıvanç Birsoy Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability Kathryn Gunn and Julie-Aurore Losman Knowledge-Based Therapeutics for Tricarboxylic Acid (TCA) Cycle-Deficient Cancers Daniel Peled, Ruth Casey, and Eyal Gottlieb Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer Alina M. Winkelkotte, Kamal Al-Shami, Adriano B. Chaves-Filho, Felix C.E. Vogel, and Almut Schulze From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments Emma Hajaj, Sabina Pozzi, and Ayelet Erez Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond Esther W. Lim and Christian M. Metallo Iron, Copper, and Selenium: Cancer’s Thing for Redox Bling Erdem M. Terzi and Richard Possemato The Complex Roles of Redox and Antioxidant Biology in Cancer Makiko Hayashi, Keito Okazaki, Thales Papgiannakopoulos, and Hozumi Motohashi The Role of Stroma in Cancer Metabolism Alec C. Kimmelman and Mara H. Sherman Cancer Metabolism under Limiting Oxygen Conditions Laura C. Kim, Nicholas P. Lesner, and M. Celeste Simon Role of Tumor Cell Intrinsic and Host Autophagy in Cancer Jessie Yanxiang Guo and Eileen White Immunometabolic Maladaptations to the Tumor Microenvironment Emma S. Hathaway, Erin Q. Jennings, and Jeffrey C. Rathmell Diet and Cancer Metabolism Jason W. Locasale, Marcus D. Goncalves, Maira Di Tano, and Guillermo Burgos-Barragan Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models Teresa W.-M. Fan, Richard M. Higashi, and Andrew N. Lane Cancer Metabolism: Aspirations for the Coming Decade Ralph J. DeBerardinis, Karen H. Vousden, and Navdeep S. Chandel Index

Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities

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