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The Biology of the TGF-β Family

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyCell BiologyImmunology and Vaccines

Edited by Rik Derynck, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at University of California San Francisco; Kohei Miyazono, University of Tokyo

Due July 2017 • 400 pages (approx.), illustrated, index
Hardcover • $135 108.00 (click here to price in UK Pounds)
ISBN  978-1-621820-36-9
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  •     Description    
  •     Contents    


The transforming growth factor β (TGF-β) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF-β family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF-β signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF-β and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF-β signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF-β signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered.

The authors also review TGF-β signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF-β and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF-β family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.


1. The Discovery and Early Days of TGF-β: A Historical Perspective
Harold L. Moses, Anita B. Roberts, and Rik Derynck
2. TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
Masato Morikawa, Rik Derynck, and Kohei Miyazono
3. Activins and Inhibins: Roles in Development, Physiology, and Disease
Maria Namwanje and Chester W. Brown
4. Bone Morphogenetic Proteins
Takenobu Katagiri and Tetsuro Watabe
5. Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
Ian B. Robertson and Daniel B. Rifkin
6. Agonists and Antagonists of the TGF- β Family Ligands
Chenbei Chang
7. Signaling Receptors for TGF-β Family Members
Carl-Henrik Heldin and Aristidis Moustakas
8. TGF-β Signaling from Receptors to Smads
Akiko Hata and Ye-Guang Chen
9. Transcriptional Control by the SMADS
Caroline S. Hill
10. Post-Translational Regulation of Smads
Pinglong Xu, Xia Lin, and Xin-Hua Feng
11. Regulation of TGF-β Family Signaling by Inhibitory Smads
Keiji Miyazawa and Kohei Miyazono
12. Structural Biology and Evolution of the TGF-β Family
Andrew P. Hinck, Thomas D. Mueller, and Tim Springer
13. Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads
Apirat Chaikuad and Alex N. Bullock
14. Non-Smad Signaling Pathways of the TGF-β Family
Ying E. Zhang
15. Signaling Crosstalk Between TGF-β/Smad and Other Signaling Pathways
Kunxin Luo
16. TGF-β Family Signaling in the Control of Cell Proliferation and Survival
Yun Zhang, Peter B. Alexander, and Xiao-Fan Wang
17. TGF-β Family Signaling in Drosophila
Ambuj Upadhyay, Lindsay Moss-Taylor, Mung-Jun Kim, Arpan C. Ghosh, and Michael B. O’Connor
18. The TGF-β Family in C. Elegans
Cathy Savage-Dunn and Richard W. Padgett
19. Keeping a Lid on Nodal: Transcriptional and Translational Repression of Nodal Signaling
Karuna Sampath and Elizabeth J. Robertson
20. TGF-β Family Signaling in Embryonic and Somatic Stem Cell Renewal and Differentiation
Alan C. Mullen and Jeffrey L. Wrana
21. TGF-β Family Signaling in Epithelial Differentiation and Epithelial to Mesenchymal Transition
Aristidis Moustakas and Kaoru Kahata
22. TGF-β family signaling in mesenchymal differentiation
Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, and Yuji Mishina
23. TGF-β Signaling in Control of Cardiovascular Function
Marie-Jose Goumans and Peter ten Dijke
24. Regulation of Hematopoiesis and Hematological Disease by TGF-β and Related Signaling
Kazuhito Naka and Atsushi Hirao
25. Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Shomyseh Sanjabi, Soyoung A. Oh, and Ming O. Li
26. TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function
Emily A. Meyers and John A. Kessler
27. The TGF-β family in the Reproductive Tract
Diana Monsivais, Martin M. Matzuk, and Stephanie A. Pangas
28. TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Elena Gallo MacFarlane, Julia Haupt, Harry C. Dietz, and Eileen M. Shore
29. TGF-β Family Signaling in Tumor Suppression and Cancer Progression
Joan Seoane and Roger R. Gomis
30. TGF-β, BMP, and Activin Signaling and the Tumor Microenvironment
Michael W. Pickup, Philip Owens, and Harold L. Moses
31. TGF-β1 Signaling and Tissue Fibrosis
Kevin K. Kim, Dean Sheppard, and Harold A. Chapman
32. TGF-β-based therapeutical approaches
Rosemary Akhurst
33. Bone Morphogenetic Proteins (BMP)-Based Therapeutic Approaches
Jonathan W. Lowery and Vicki Rosen