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Cell-Cell Junctions

Subject Area(s):  Developmental BiologyCell BiologyMolecular Biology

Edited by W. James Nelson, Stanford University; Elaine Fuchs, The Rockefeller University

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© 2010 • 443 pp., illus., index
Hardcover • $135 67.50 (click here to price in UK Pounds)
ISBN  978-0-879698-84-3
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Cell-cell junctions are multi-molecular complexes that link neighboring cells. They help maintain tissue integrity, act as barriers to permeability, and allow intercellular transport. They also reinforce cell polarity by separating the apical and basolateral domains of the plasma membrane.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering each of the main junction types—tight junctions, adherens junctions, and desmosomes—as well as the more specialized junctions of neuronal and immune cells. The contributors examine the assembly and structure of different cell junctions, their roles in cellular signal transduction, and their importance during development and normal tissue homeostasis.

Including discussion of the roles of junctions in various diseases, this volume is a vital reference for cell and developmental biologists wishing to know how cells interact in multicellular organisms.


Historical Perspective
Discovering the Molecular Components of Intercellular Junctions—A Historical View
Werner W. Franke
Overview of Junction Organization
Molecular Basis of the Core Structure of Tight Junctions
Mikio Furuse
Adherens Junction: Molecular Architecture and Regulation
Wenxiang Meng and Masatoshi Takeichi
Gap Junctions
Daniel A. Goodenough and David L. Paul
The Desmosome
Emmanuella Delva, Dana K. Tucker, and Andrew P. Kowalczyk
Structural Organization of Junctions
Structure and Biochemistry of Cadherins and Catenins
Lawrence Shapiro and William I. Weis
Physiology and Function of the Tight Junction
James M. Anderson and Christina M. Van Itallie
Junction Dynamics and Assembly
Molecular Bases of Cell-Cell Junctions Stability and Dynamics
Matthieu Cavey and Thomas Lecuit
Intercellular Junction Assembly, Dynamics, and Homeostasis
Kathleen J. Green, Spiro Getsios, Sergey Troyanovsky, and L.M. Godsel
Junction Signaling
Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development
Ewa Stepniak, Glenn L. Radice, and Valeri Vasioukhin
Interplay of Cadherin-mediated Cell Adhesion and Canonical Wnt Signaling
Julian Heuberger and Walter Birchmeier
Wnt Signaling from Development to Disease: Insights from Model Systems
Ken M. Cadigan and Mark Peifer
Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases
Takashi Watanabe, Kazuhide Sato, and Kozo Kaibuchi
Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity
Pierre D. McCrea, Dongmin Gu, and Maria S. Balda
Complex Junction Organization
Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives
Nikolaos Giagtzoglou, Cindy V. Ly, and Hugo J. Bellen
Modular Design of Immunological Synapses and Kinapses
Michael L. Dustin
Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell Interactions
Vann Bennett and Jane Healy
Planar Cell Polarity: Keeping Hairs Straight Is Not So Simple
Helen McNeill
Junctions as Targets for Disease
Listeria monocytogenes Internalin and E-cadherin: From Bench to Bedside
Matteo Bonazzi, Marc Lecuit, and Pascale Cossart
Cadherins as Targets for Genetic Diseases
Aziz El-Amraoui and Christine Petit
Involvement of Members of the Cadherin Superfamily in Cancer
Geert Berx and Frans van Roy

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