Contents

Preface

Deciphering Alzheimer Disease

Dennis Selkoe, Eckhard Mandelkow, and David Holtzman

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Rawan Tarawneh and David M. Holtzman

The Neuropsychological Profile of Alzheimer Disease

Sandra Weintraub, Alissa H. Wicklund, and David P. Salmon

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo, Matthew P. Frosch, Eliezer Masliah, and Bradley T. Hyman

Brain Imaging in Alzheimer Disease

Keith A. Johnson, Nick C. Fox, Reisa A. Sperling, and William E. Klunk

Fluid Biomarkers in Alzheimer Disease

Kaj Blennow, Henrik Zetterberg, and Anne M. Fagan

Epidemiology of Alzheimer Disease

Richard Mayeux and Yaakov Stern

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

Eva-Maria Mandelkow and Eckhard Mandelkow

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini

Biochemistry of Amyloid β-Protein and Amyloid Deposits in Alzheimer Disease

Colin L. Masters and Dennis J. Selkoe

Trafficking and Proteolytic Processing of APP

Christian Haass, Christoph Kaether, Gopal Thinakaran, and Sangram Sisodia

Physiological Functions of APP Family Proteins

Ulrike C. Müller and Hui Zheng

The Genetics of Alzheimer Disease

Rudolph E. Tanzi

Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

Bart De Strooper, Takeshi Iwatsubo, and Michael S. Wolfe

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

David M. Holtzman, Joachim Herz, and Guojun Bu

Animal Models of Alzheimer Disease

Frank M. LaFerla and Kim N. Green

Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction

Lennart Mucke and Dennis J. Selkoe

Inflammation in Alzheimer Disease—A Brief Review of the Basic Science and Clinical Literature

Tony Wyss-Coray and Joseph Rogers

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease

Yasuo Ihara, Maho Morishima-Kawashima, and Ralph Nixon

Proteolytic Degradation of Amyloid β-Protein

Takaomi Saido and Malcolm A. Leissring

Neurovascular Dysfunction and Faulty Amyloid β-Peptide Clearance in Alzheimer Disease

Abhay P. Sagare, Robert D. Bell, and Berislav V. Zlokovic

Treatment Strategies Targeting Amyloid β-Protein

Dale Schenk, Guriqbal S. Basi, and Menelas N. Pangalos

Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets

Virginia M.-Y. Lee, Kurt R. Brunden, Michael Hutton, and John Q. Trojanowski

Symptomatic and Nonamyloid/Tau Based Pharmacologic Treatment for Alzheimer Disease

Paul S. Aisen, Jeffrey Cummings, and Lon S. Schneider

Alzheimer Disease in 2020

David M. Holtzman, Eckhard Mandelkow, and Dennis J. Selkoe

Index

  “Anyone following the primary literature on Alzheimer’s disease research knows that keeping abreast of this rapidly evolving field has become a Herculean task. More and more data are being published on ever-diversifying lines of research, and they are not made any clearer by discrepancies among studies and debate about what is important. It’s a challenge for newcomers and Alzheimerologists alike to see the big picture of what has been learned and where the field is heading....The Biology of Alzheimer Disease, published in 2012 by Cold Spring Harbor Laboratory Press, attempts to help with that....The editors and authors address a broad audience of people from across biomedical research, particularly students and junior researchers, but also investigators in related fields of science and those with a passing interest in Alzheimer’s...The total collection stands out for pulling together a broad swath of leading scientists internationally to work toward the shared goal of articulating what is the agreed-upon state of the art in their field.”
      —Alzheimer Research Form