© 2024 • 300 pages (approx.), illustrated (37 color), index
Hardcover • $61.62 • ISBN 978-1-621824-66-4

Breast cancer is diagnosed in over two million people each year and kills more than six hundred thousand. It has numerous histological subtypes, each with different molecular properties, and a variety of genetic and environmental factors increase an individual’s risk of developing the disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of breast cancer epidemiology, the molecular and cellular mechanisms underlying its progression, and recent advances in tumor prevention, detection and treatment. The contributors discuss how work using animal models, patient-derived xenografts, and organoid cultures, together with new imaging approaches, is providing new insights into the molecular pathology of breast cancer. In addition, they examine genetic and genomic determinants, the role of chromatin, and research into intra- and inter-tumor heterogeneity.

The authors also discuss tumor dormancy, the importance of the immune system in breast cancer, and ways this may be harnessed in tumor immunotherapy. This volume is therefore a vital reference for all biologists seeking to understand the biological basis of cancer, as well as immunologists and oncologists dedicated to combating this deadly disease.

Preface

Breast Cancer Histopathology in The Age of Molecular Oncology

Zuzana Kos, Torsten O. Nielsen, Anne-Vibeke Laenkholm

Epidemiology and Risk Factors for Breast Cancer: 21st Century Advances, Gaps to Address Through Interdisciplinary Science

Mary Beth Terry and Graham A. Colditz

Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk-Evaluation

Siddhartha Yadav, Fergus J. Couch, and Susan M. Domchek

Human Ductal Carcinoma in Situ: Advances and Future Perspectives

Fariba Behbod, Jennifer H. Chen, and Alastair Thompson

Gene Expression Profiling to Decipher Breast Cancer Inter- and Intra-Tumor Heterogeneity

Alexander Swarbrick, Aranzazu Fernandez-Martinez, and Charles M. Perou

Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer

Shalini Bahl, Jason S. Carroll, and Mathieu Lupien

The Breast Cancer Proteome and Precision Oncology

Jonathan T. Lei, Eric J. Jaehnig, Hannah Smith, Matthew V. Holt, Xi Li, Meenakshi Anurag, Matthew J. Ellis, Gordon B. Mills, Bing Zhang, and Marilyne Labrie

Mechanisms of Organ-Specific Metastasis of Breast Cancer

Emma Nolan, Yibin Kang, and Ilaria Malanchi

Dormancy in Breast Cancer

Erica Dalla, Amulya Sreekumar, Julio Aguirre-Ghiso, and Lewis A. Chodosh

Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges

Senthil K. Muthuswamy and Joan S. Brugge

Advances in Immunocompetent Mouse and Rat Models

Wen Bu and Yi Li

The Power and Promise of Patient-Derived Xenografts of Human Breast Cancer

Michael T. Lewis and Carlos Caldas

Multi-Dimensional Imaging of Breast Cancer

Anne C. Rios, Jacco van Rheenen, and Colinda L.G.J. Scheele

Spatial Biology of Breast Cancer

H. Raza Ali and Robert B. West

Breast Cancer Immunity: It is TIME for the Next Chapter

Daniela F. Quail, Morag Park, Alana L. Welm, and H. Atakan Ekiz

Immunotherapy Approaches for Breast Cancer Patients in 2023

Leisha A. Emens and Sherene Loi

Emerging Therapies for Breast Cancer

Shom Goel and Sarat Chandarlapaty

Index