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Gastrulation: From Cells to Embryo

Subject Area(s):  Developmental Biology

Edited by Claudio D. Stern, University College London

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© 2004 • 731 pp., illus., appendices, index
Printed hardcover •
ISBN  978-087969707-5

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  •     Description    
  •     Contents    
  •     Reviews    


During gastrulation, tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.


1. Sucking in the Gut: A Brief History of Early Studies on Gastrulation
    S. Brauckmann and S.F. Gilbert
Part I: The Embryology of Gastrulation
2. Gastrulation in Sponges
    S.P. Leys
3. Gastrulation in the Cnidaria and Ctenophora
    C.A. Byrum and M.Q. Martindale
4. Gastrulation in Nematodes
    J. Nance and J.R. Priess
5. Gastrulation in the Molluscan Embryo
    J.A.M. van den Biggelaar and W.J.A.G. Dictus
6. Gastrulation in Crustaceans: Germ Layers and Cell Lineages
    M. Gerberding and N.H. Patel
7. Gastrulation in Drosophila
    M. Leptin
8. Gastrulation in Other Insects
    S. Roth
9. Sea Urchin Gastrulation
    D.R. McClay, J.M. Gross, R. Range, R.E. Peterson, and C. Bradham
10. Protochordate Gastrulation: Lancelets and Ascidians
      B.J. Swalla
11. Gastrulation in a Chondrichthyan, the Dogfish Scyliorhinus canicula
      T. Sauka–Spengler, J.–L. Plouhinec, and S. Mazan
12. Teleost Gastrulation
      D.A. Kane and R.M. Warga
13. Gastrulation in Amphibians
      R. Keller and D. Shook
14. Gastrulation in Reptiles
      E.H. Gilland and A.C. Burke
15. Gastrulation in the Chick
      C.D. Stern
16. Gastrulation in the Mouse Embryo
      P.P.L. Tam and J.M. Gad
17. Gastrulation in the Rabbit
      C. Viebahn
18. Gastrulation in Other Mammals and Humans
      G.S. Eakin and R.R. Behringer
Part II: Cellular Events of Gastrulation
19. Cell Movements of Gastrulation
      R. Keller and L. Davidson
20. Morphogenetic Cellular Flows during Zebrafish Gastrulation
      R.J. Adams and C.B. Kimmel
21. Cell–Substrate Interactions during Deuterostome Gastrulation
      C.A. Ettensohn and R. Winklbauer
22. Chemotaxis in Coordinating Cell Movements during Gastrulation
      C.J. Weijer
23. Symmetry Breaking in the Egg of Xenopus laevis
      J. Gerhart
24. Breaking Radial Symmetry: Amniote Type
      S. Frankenberg and M. Zernicka–Goetz
25. Vertebrate Mesoderm Induction: From Frogs to Mice
      D. Kimelman and C. Bjornson
26. Dorsoventral Patterning of the Mesoderm
      R. Harland
27. Early Rostrocaudal Patterning of the Mesoderm and Neural Plate
      S.E. Fraser and C.D. Stern
28. Early Patterning of the Left/Right Axis
      D.S. Adams and M. Levin
29. Neural Induction
      C.D. Stern
30. Endoderm Development
      A. Grapin–Botton and D. Constam
31. Extraembryonic Tissues
      K.M. Downs
Part III: The Molecular Biology of Gastrulation
Signaling Pathways
32. FGF Signaling during Gastrulation
      J. Sivak and E. Amaya
33. Modulation of BMP Signaling during Vertebrate Gastrulation
      I. Muñoz–Sanjuán and A.H. Brivanlou
34. Nodal Signaling during Gastrulation
      A.F. Schier
35. Activin and Vg1 and the Search for Embryonic Inducers
      D.S. Kessler
36. The Role of Wnts in Gastrulation
      D.W. Houston and C. Wylie
37. Roles of Notch during Gastrulation
      D.R. McClay, R. Peterson, and R. Range
38. Retinoid Signaling during Gastrulation
      M. Maden
Transcription Factors
39. Role of Otx2 during Gastrulation
      A. Simeone
40. Function of the Winged Helix Transcription
      Factor HNF3β/FoxA2 during Gastrulation
      D.C. Weinstein
41. Role of T–Box Genes during Gastrulation
      J.C. Smith
42. Goosecoid and Gastrulation
      E.M. De Robertis
43. Roles of Lim1 during Gastrulation
      W. Shawlot and R.R. Behringer
44. Not Homeobox Gene Function in Axial Mesoderm Development
      S. Mackem
45. Role of Siamois before and during Gastrulation
      L. Kodjabachian and P. Lemaire
46. Conserved and Divergent Roles of Twist in Gastrulation
      A. Tapanes–Castillo, V. Cox, and M. Baylies
47, The Snail Gene Family during Gastrulation
      A.V. Morales and M.A. Nieto
48. System–level Properties Revealed by a Gene Regulatory
      Network Analysis of Pre–gastrular Specification in Sea Urchins
      V.F. Hinman and E.H. Davidson
Extracellular Components
49. The Extracellular Matrix of the Deuterostome Gastrula
      R. Winklbauer and C.A. Ettensohn
50. Carbohydrate and Lipid Modification of Developmental Signaling Molecules
      K. Nybakken and N. Perrimon
Part IV: The Evolution of Gastrulation
51. Comparative Aspects of Gastrulation
      D. Arendt
52. The Evolution of Gastrulation: Cellular and Molecular Aspects
      A.L. Price and N.H. Patel
53. Fossil Embryos
      S. Conway Morris
Part V: Open Questions
54. Gastrulation Overview: Open Questions
      L. Wolpert


review:  “I enthusiastically recommend this book, and expect it will be highly valuable to students, teachers and researchers. The book provides a comprehensive, authoritative and modern view of our knowledge of gastrulation, and captures the excitement in this rapidly developing field. I imagine that many young readers will become intrigued by gastrulation and at least a few will become hooked by it forever after reading this book.”

review:  “The coverage of key topics within each chapter is comprehensive and well illustrated with numerous figures and the effort made to keep the styles of writing and illustrations consistent between chapters is helpful. The different chapters, each one written by experts in the field, not only give us the facts, but also clearly communicate the enthusiasm that the authors have for their topics.”
      —Nature Cell Biology

review:  “This book is essential reading for biology teachers and scientists interested in developmental biology. The technical jargon is kept to a minimum and the glossary, placed at the beginning, can make any prospective reader comfortable....The photos and figures are truly magnificent, something for which developmental biologists have a reputation. In addition, there are supplemental data and gastrulation movies on several species at the accompanying Web site (”
      —The American Biology Teacher

review:  “Stern is to be congratulated on the organization of [this] volume, which analyzes gastrulation on a series of structural and functional levels. This is the most logical and satisfying way to present such a complex subject to either an audience of experts or to students....

This book will be the reference on gastrulation for many years to come. I would recommend it highly to any developmental biologist, whether their research is in the area of gastrulation or not. I would also recommend it as a text or reference for an advanced undergraduate or graduate topics course that might want to use gastrulation as a focus area.”
      —Developmental Dynamics

review:  “The book succeeds by not limiting discussion to today's most popular model organisms and trendy molecules, but by including many organisms that have virtually disappeared from meeting presentations. The book contains 54 chapters separated into five parts that cover embryology, cell biology, molecular biology, evolution, and a brief overview of remaining questions. Chapter authors were encouraged to cite the primary literature in lieu of reviews, which should ensure that the book stands as a lasting resource for current and future developmental biologists. Intended for researchers, teachers, and students, some chapters will be accessible to all, while others will only be readily understood by advanced readers....It is a treat to skip through the chapters of this book. Readers will find it worth the price, and I thank Stern and Cold Spring Harbor Laboratory Press for compiling this snapshot of gastrulation studies at the turn of the 21st century.”
      —The Quarterly Review of Biology