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Cancer Evolution

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression.

The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

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Preface
The Role of Aneuploidy in Cancer Evolution
Index

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Description
Contents
   

© 2017 • 304 pages, illustrated (62 color and 5 B&W), index
Hardcover • $75.00 • ISBN 978-1-621821-43-4


 

Description

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression.

The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

 
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Contents

Preface
Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
Angelo Fortunato, Amy Boddy, Diego Mallo, Athena Aktipis, Carlo C. Maley, and John W. Pepper
Big Bang Tumor Growth and Clonal Evolution
Ruping Sun, Zheng Hu, and Christina Curtis
Order Matters: The Order of Somatic Mutations Influences Cancer Evolution
David G. Kent and Anthony R. Green
Principles of Reconstructing the Subclonal Architecture of Cancers
Stefan C. Dentro, David C. Wedge, and Peter Van Loo
Phylogenetic Quantification of Intratumor Heterogeneity
Thomas B.K. Watkins and Roland F. Schwarz
Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution
Samuel F. Bakhoum and Dan Avi Landau
The Role of Aneuploidy in Cancer Evolution
Laurent Sansregret and Charles Swanton
Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution
Subramanian Venkatesan, Charles Swanton, Barry S. Taylor, and Joseph F. Costello
The Cellular Origin and Evolution of Breast Cancer
Mei Zhang, Adrian V. Lee, and Jeffrey M. Rosen
Evolution of Premalignant Disease
Kit Curtius, Nicholas A. Wright, and Trevor A. Graham
Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer
David Basanta and Alexander R.A. Anderson
Coevolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia
Noelia Purroy and Catherine J. Wu
Spatial Heterogeneity in the Tumor Microenvironment
Yinyin Yuan
Tumor Microenvironment and Differential Responses to Therapy
Eishu Hirata and Erik Sahai
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity
John D. Martin, Dai Fukumura, Dan G. Duda, Yves Boucher, and Rakesh K. Jain
Observing Clonal Dynamics across Spatiotemporal Axes: A Prelude to Quantitative Fitness Models for Cancer
Andrew W. McPherson, Fong Chun Chan, and Sohrab P. Shah
Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies
Mariangela Russo and Alberto Bardelli
The Evolution and Ecology of Resistance in Cancer Therapy
Robert Gatenby and Joel Brown
The “Achilles’ Heel” of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies
Kroopa Joshi, Benjamin M. Chain, Karl S. Peggs, and Sergio A. Quezada
Index
 

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Cancer Evolution