` Cold Spring Harbor Laboratory Press Site Map and Book List

Cold Spring Harbor Laboratory Press Site Map and Book List


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Title   Abraham Lincoln's DNA and Other Adventures in Genetics
Unique URL   http://www.cshlpress.com/link/alincpap.htm
ISBN978-087969649-8
Price$16
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Twenty-four true, wide-ranging tales of crime, history, human behavior,
illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Author
  Philip R. ReillyInterleukin Genetics and Tufts University School of Medicine
Publication Date2000/2000
Bibliographic Information
339 pp., illus., indexes, references
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Related Products Abraham Lincoln's DNA and Other Adventures in Genetics
The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives
Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family

Title   Addiction
Unique URL   http://www.cshlpress.com/link/addiction.htm
ISBN978-1-936113-47-7
Price$135
Series Information: 

Drug and alcohol abuse elicits significant biological changes in the brain that drive compulsive behavior and lead to addiction. Abrupt cessation leads to withdrawal, craving, and relapse. A complete understanding of the brain changes produced by abused substances is therefore necessary if we are to develop treatments for drug dependence.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine explores the biological basis of addiction to alcohol, nicotine, and other psychoactive drugs. Contributors describe the molecular targets of these drugs, the resulting changes to neural networks, and the various genetic, developmental, and behavioral factors that influence the progression from abuse to addiction. Animal models of addictive behavior and techniques to dissect neural circuits are also described.


This volume includes discussion of compounds currently used or under development to treat drug dependence. Thus, it is an indispensable reference for neuroscientists and all who are interested in reducing the public health burden of substance abuse.


Editor
  R. Christopher PierceUniversity of Pennsylvania
Publication Date2013/2013
Bibliographic Information
368 pp., illus (30 4C and 25 B&W), index
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Title   Adult Neurogenesis
Unique URL   http://www.cshlpress.com/link/adultneuro.htm
ISBN978-087969784-6
Price$135
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The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this collection from Cold Spring Harbor Perspectives in Biology provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.
Editor
  Fred H. GageThe Salk Institute for Biological Studies, San Diego, California
Publication Date2008/2008
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673 pp., illus, index
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Title   Ageless Quest: One Scientist's Search for the Genes That Prolong Youth
Unique URL   http://www.cshlpress.com/link/ageless.htm
ISBN978-087969652-8
Price$19.95
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Ageless Quest is a personal, sometimes controversial, account of the pursuit of a genetic ‘cure’ for aging by an expert in the field.


The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology.


Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging.


Lenny Guarente's Ageless Quest is a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward—and equally high risk.


To read Lenny Guarente’s and Robert Butler’s interview with Sara Davidson (The NY Times) about how the body ages and the research on trying to extend our healthy life span, click here. (You must register for free access to NYTimes.com)

Author
  Lenny GuarenteMassachusetts Institute of Technology
Publication Date2003/2003
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154 pp., illus., index
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Title   An A to Z of DNA Science: What Scientists Mean When They Talk about Genes and Genomes
Unique URL   http://www.cshlpress.com/link/a2zgenes.htm
ISBN978-087969600-9
Price$16
Series Information: 
Medical science constantly demands our attention, as patients or relatives, concerned citizens, voters, investors, or simply curious individuals. But for those without training, the language of science is often hard to follow. The A to Z of DNA Science book series defines and illustrates specialized terms in ways that non-specialists can appreciate and enjoy. This volume focuses on the language of genes, genomes, DNA, biotechnology, and heredity, defining, explaining, and illustrating over 200 terms used in books, broadcasting, websites, and newspaper and magazine articles.
Author
  Jeffre L. WitherlyNational Human Genome Research Institute, Bethesda, Maryland
Publication DateSeptember 2001/2001
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126 pp., illus., index
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Title   An Illustrated Chinese-English Guide for Biomedical Scientists
Unique URL   http://www.cshlpress.com/link/chinengp.htm
ISBN978-087969648-1
Price$25
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The Illustrated Chinese–English Guide for Biomedical Scientists is intended to build confidence in the use of English scientific language.  The book lists terms that are in common use in science laboratories, translated into both simplified and complex Chinese. It also contains illustrations of equipment, labeled in both languages.
Author
  James M. Samet
Publication Date2004/2004
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115 pp., illus., illustrations index
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Related Products An Illustrated Chinese-English Guide for Biomedical Scientists

Title   An Illustrated Chinese-English Guide for Biomedical Scientists
Unique URL   http://www.cshlpress.com/link/chineng.htm
ISBN978-087969701-3
Price$39
Series Information: 
The Illustrated Chinese–English Guide for Biomedical Scientists is intended to build confidence in the use of English scientific language.  The book lists terms that are in common use in science laboratories, translated into both simplified and complex Chinese. It also contains illustrations of equipment, labeled in both languages.
Author
  James M. Samet
Publication Date2004/2004
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115 pp., illus., illustrations index
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Related Products An Illustrated Chinese-English Guide for Biomedical Scientists

Title   An Introduction to Animal Behavior: An Integrative Approach
Unique URL   http://www.cshlpress.com/link/introanibeh.htm
ISBN978-1-936113-18-7
Price$81.00
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The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.
Author
  Michael J. RyanThe University of Texas at Austin
Publication Date2011/2011
Bibliographic Information
258 pp., illus. (88 color, 3 b/w), index
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Evolution
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Title   An Introduction to Animal Behavior: An Integrative Approach
Unique URL   http://www.cshlpress.com/link/introanibehp.htm
ISBN978-0-879698-58-4
Price$46.00
Series Information: 
The study of animal behavior is one of the most integrative endeavors in biology—it encompasses how the behavior is acquired, how it works, why it has come to work as it does, and how it influences the behaving animal and the animals around it. In Animal Behavior: An Integrative Approach, Michael J. Ryan and Walter Wilczynski address the interrelationship of these aspects of animal behavior, which Nikolaas Tinbergen codified in his “four questions” as causation, ontogeny, survival value, and evolution. In light of these questions, the authors first review some of the basic concepts of ultimate and proximate aspects of behavior. They make the argument that integrating different levels of analysis is critical for deriving a correct interpretation of behavior. In subsequent chapters, they review topics such as foraging, orientation and migration, sex differences, mate choice, social bonding, cooperation, conflict, and aggression. The authors integrate information from molecular genomics through neuroscience, endocrinology, development, and learning to evolutionary genetics, selection, constraints, and phylogenetics to provide a concise but comprehensive look at current topics in animal behavior. This book provides a well-thought-out and integrated introduction to the complexity of animal behavior that should appeal to advanced undergraduates, graduate students, and professional scientists in other fields in need of a succinct review of the field.
Author
  Michael J. RyanThe University of Texas at Austin
Publication Date2011/2011
Bibliographic Information
258 pp., illus. (88 color, 3 b/w), index
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Related Products An Introduction to Animal Behavior: An Integrative Approach
Evolution
An Introduction to Nervous Systems
An Introduction to Nervous Systems

Title   An Introduction to Nervous Systems
Unique URL   http://www.cshlpress.com/link/wrldfndp.htm
ISBN978-087969821-8
Price$46.00
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An Introduction to Nervous Systems presents the principles of neurobiology from an evolutionary perspective—from single–celled organisms to complex invertebrates such as flies—and is ideal for use as a supplemental textbook. Greenspan describes the mechanisms that allow behavior to become ever more sophisticated—from simple avoidance behavior of Paramecium through to the complex cognitive behaviors of the honeybee—and shows how these mechanisms produce the increasing neural complexity found in these organisms. The book ends with a discussion of what is universal about nervous systems and what may be required, neurobiologically, to be human. This novel and highly readable presentation of fundamental principles of neurobiology is designed to be accessible to undergraduate and graduate students not already steeped in the subject.
Author
  Ralph J. GreenspanThe Neurosciences Institute, San Diego, California
Publication Date2007/2007
Bibliographic Information
172 pp., illus., bibliography, glossary, index
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Related Products An Introduction to Nervous Systems
Fly Pushing: The Theory and Practice of Drosophila Genetics, Second Edition
Invertebrate Neurobiology
Drosophila Neurobiology: A Laboratory Manual
Drosophila Neurobiology: A Laboratory Manual



Title   An Introduction to Nervous Systems
Unique URL   http://www.cshlpress.com/link/wrldfnd.htm
ISBN978-087969757-0
Price$67.00
Series Information: 
An Introduction to Nervous Systems presents the principles of neurobiology from an evolutionary perspective—from single–celled organisms to complex invertebrates such as flies—and is ideal for use as a supplemental textbook. Greenspan describes the mechanisms that allow behavior to become ever more sophisticated—from simple avoidance behavior of Paramecium through to the complex cognitive behaviors of the honeybee—and shows how these mechanisms produce the increasing neural complexity found in these organisms. The book ends with a discussion of what is universal about nervous systems and what may be required, neurobiologically, to be human. This novel and highly readable presentation of fundamental principles of neurobiology is designed to be accessible to undergraduate and graduate students not already steeped in the subject.
Author
  Ralph J. GreenspanThe Neurosciences Institute, San Diego, California
Publication Date2007/2007
Bibliographic Information
172 pp., illus., bibliography, glossary, index
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Fly Pushing: The Theory and Practice of Drosophila Genetics, Second Edition
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Title   Angiogenesis: Biology and Pathology
Unique URL   http://www.cshlpress.com/link/angiogenesis.htm
ISBN978-1-936113-43-9
Price$135
Series Information: 

Angiogenesis is the process by which new blood vessels are generated from preexisting vessels. It is vital for proper embryonic development, patterning of the vascular system, and wound healing. It is rate limiting in cancer progression, because the formation of new blood vessels is essential for growth and survival of tumors.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer. The contributors review the biology of endothelial cells, describing the specific roles of tip and stalk cells in vessel sprouting and lumen formation. They discuss the key angiogenic regulators (e.g., vascular endothelial growth factor [VEGF]), as well as antiangiogenic agents including microRNAs, thrombospondins, and semaphorins. Therapeutic approaches that target pathological angiogenesis, such as the ongoing clinical trials of anti-VEGF drugs, are also covered.


This volume, which includes discussions of other vascular dysfunctions (e.g., arteriovenous malformations) and comparisons between the blood vascular system and the lymphatic system, is a vital reference for developmental and cancer biologists, as well as anyone seeking to understand the biology and pathology of the vascular system.



Editor
  Michael KlagsbrunChildren's Hospital Boston
Publication DateDecember 2011/2011
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522 pp., illus. (62 4C and 11 B&W), index
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Title   The Annotated and Illustrated Double Helix
Unique URL   http://www.cshlpress.com/link/autoillus.htm
ISBN978-1-476715-49-0
Price$Not for Sale
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The structure of DNA deduced by James Watson and Francis Crick in 1953 was one of the most significant scientific discoveries of the 20th century. Fifteen years later, Watson wrote The Double Helix, his classic account of the discovery. It was something new, a description of science in action written not as a formal autobiography or a measured history, but in the voice of a brash, ambitious young man who knew the big question in biology and wanted the answer.

In this edition, Watson’s text is unchanged, but Alex Gann and Jan Witkowski have added over three hundred annotations on the events and characters portrayed, with facsimile letters and contemporary photographs, many previously unpublished. Their sources include newly discovered correspondence from Crick, the papers of Franklin, Pauling, and Wilkins, and they include a chapter dropped from the original edition.


The Double Helix is recognized by the Library of Congress as “A Book That Shaped America”. This new edition, published to mark the 50th anniversary of the Nobel Prize for Watson, Crick, and Wilkins, and the 60th anniversary of the discovery itself, adds depth and richness to one of the most famous stories in science.


“The Double Helix is the best book I know about a scientific discovery—this new edition suffuses the whole with social history, fascinating documentation, photography, and cunning background research. The early fifties, the beginning of the modern age of molecular biology, spring to life.“ ——Ian McEwan, author of Atonement



“The Double Helix is an extraordinary book: a thrilling, novelistic account of one of the most surprising of all scientific discoveries. This new edition draws upon a remarkable and eclectic archive of information to bring to life the stories of those who found the secret of life.“ — Matt Ridley, author of Genome and Francis Crick

Author
  James D. WatsonCold Spring Harbor Laboratory
Publication Date2013/2013
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345 pages, illus. (320 B&W), index
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Title   Antibodies: A Laboratory Manual, Second edition
Unique URL   http://www.cshlpress.com/link/antibodies2.htm
ISBN978-1-936113-80-4
Price$260
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It has been 25 years since the now classic lab manual Antibodies, by Harlow and Lane appeared. This second edition of Antibodies, edited by Edward A. Greenfield of the Dana-Farber Cancer Institute builds on the core strengths of the first edition, presenting clear and authoritative protocols with extensive background information and troubleshooting advice. The original introductory chapters have been recast and updated to take into account our current understanding of the immune system. The critical chapters on generating monoclonal antibodies and growing hybridomas, which demystified hybridoma generation, have been greatly expanded and updated to make these procedures easy to follow and adaptable to current research needs. The remaining chapters contain all new protocols and topics and reflect the progress in how antibodies are studied and used since the appearance of the original edition. These include:

  • antibody purification and storage
  • engineering antibodies, including use of degenerate oligonucleotides, 5’-RACE, phage display, and mutagenesis
  • extensive labeling techniques
  • new immunoblotting protocols
  • the latest screening and labeling techniques

As Dr. Greenfield notes in his preface to this second edition:
"The Antibodies manual provided our laboratory with guidance in the form of protocols and recommendations for setting up a hybridoma facility. Everything we needed to know to make a monoclonal antibody was all there, neatly packaged in an easy-to-understand book….the second edition is intended to provide the necessary information and protocols to assist investigators with their first monoclonal antibody effort as well as to provide guidance for more experiences antibody makers who are having some difficulties with a particular project."



What’s New in This Edition?


I have the first edition. Why should I buy the second edition?



While the core of the first edition appears in updated and recast form in the second edition, more than half of the second edition contains entirely new information and protocols to reflect the changes in the field since the first edition.



To whom is this edition addressed? Is this a book for immunologists?



As with the first edition, the second edition provides information and protocols for both the neophyte and the experienced investigator. It dissects the mysteries of producing the antibodies and reagents you need for your experiments with the needs of molecular biologists in mind. It is the perfect book for new members of your lab as it has sufficient background information to provide context as well as clear, step-by-step instructions for performing the needed experiments—both the why and the how for these techniques. And if things go wrong, there is extensive troubleshooting to diagnose the problem.


Are the protocols in this book better than those available for download on the Web?


Many of the protocols available on the Web are perfectly good, but there are many that are not. Reagents are expensive and deadlines are tight. CSHL Press manuals provide protocols that have been formulated and tested in the labs of leading investigators in the field. They are reliable and they work. And they include the context and troubleshooting information that many online protocols do not have.

Editor
  Edward A. GreenfieldDana-Farber Cancer Institute
Publication Date2014/2014
Bibliographic Information
847 pp., illus. (32 4C, 103 B&W), index
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Title   Antibodies: A Laboratory Manual, Second edition
Unique URL   http://www.cshlpress.com/link/antibodies2p.htm
ISBN978-1-936113-81-1
Price$175
Series Information: 
It has been 25 years since the now classic lab manual Antibodies, by Harlow and Lane appeared. This second edition of Antibodies, edited by Edward A. Greenfield of the Dana-Farber Cancer Institute builds on the core strengths of the first edition, presenting clear and authoritative protocols with extensive background information and troubleshooting advice. The original introductory chapters have been recast and updated to take into account our current understanding of the immune system. The critical chapters on generating monoclonal antibodies and growing hybridomas, which demystified hybridoma generation, have been greatly expanded and updated to make these procedures easy to follow and adaptable to current research needs. The remaining chapters contain all new protocols and topics and reflect the progress in how antibodies are studied and used since the appearance of the original edition. These include:

  • antibody purification and storage
  • engineering antibodies, including use of degenerate oligonucleotides, 5’-RACE, phage display, and mutagenesis
  • extensive labeling techniques
  • new immunoblotting protocols
  • the latest screening and labeling techniques

As Dr. Greenfield notes in his preface to this second edition:
"The Antibodies manual provided our laboratory with guidance in the form of protocols and recommendations for setting up a hybridoma facility. Everything we needed to know to make a monoclonal antibody was all there, neatly packaged in an easy-to-understand book….the second edition is intended to provide the necessary information and protocols to assist investigators with their first monoclonal antibody effort as well as to provide guidance for more experiences antibody makers who are having some difficulties with a particular project."



What’s New in This Edition?


I have the first edition. Why should I buy the second edition?



While the core of the first edition appears in updated and recast form in the second edition, more than half of the second edition contains entirely new information and protocols to reflect the changes in the field since the first edition.



To whom is this edition addressed? Is this a book for immunologists?



As with the first edition, the second edition provides information and protocols for both the neophyte and the experienced investigator. It dissects the mysteries of producing the antibodies and reagents you need for your experiments with the needs of molecular biologists in mind. It is the perfect book for new members of your lab as it has sufficient background information to provide context as well as clear, step-by-step instructions for performing the needed experiments—both the why and the how for these techniques. And if things go wrong, there is extensive troubleshooting to diagnose the problem.


Are the protocols in this book better than those available for download on the Web?


Many of the protocols available on the Web are perfectly good, but there are many that are not. Reagents are expensive and deadlines are tight. CSHL Press manuals provide protocols that have been formulated and tested in the labs of leading investigators in the field. They are reliable and they work. And they include the context and troubleshooting information that many online protocols do not have.

Editor
  Edward A. GreenfieldDana-Farber Cancer Institute
Publication Date2014/2014
Bibliographic Information
847 pp., illus. (32 4C, 103 B&W), index
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Title   At the Bench: A Laboratory Navigator, Updated Edition
Unique URL   http://www.cshlpress.com/link/atbench2.htm
ISBN978-087969708-2
Price$61.00
Series Information: 

At the Bench is the unique and hugely successful handbook for living and working in the laboratory, an essential aid to understanding basic lab techniques and how research groups work at a human level. In this newly revised edition, chapters have been rewritten to accommodate the impact of computer technology and the Internet, not only on the acquisition and analysis of data, but also on its organization and presentation. Alternatives to the use of radiation have been expanded, and figures and illustrations have been redrawn to reflect changes in laboratory equipment and procedures.


Wise, light-hearted, but thoroughly practical, Dr. Barker offers advice, moral support, social etiquette, and professional reassurance along with assume-nothing, step-by-step instructions for those basic but vital laboratory procedures that experienced investigators know—but may not realize novices don’t.

If you are a graduate student, a physician with research intentions, or a laboratory technician, this book is indispensable. If you have to manage or mentor such people, giving a copy to each of them will greatly improve your life, and theirs.


About the author: Kathy Barker received her B.A. in Biology and English, and her M.A. and Ph.D. in Microbiology, from various branches of the University of Massachusetts. She did her postdoctoral work in the laboratory of Viral Oncology at Rockefeller University and was an Assistant Professor in the Laboratory of Cell Physiology and Immunology at Rockefeller University. She is now based in Seattle, where she writes and gives workshops on various aspects of running a lab.



Dr. Barker invites you to send any comments or questions to her.

Author
  Kathy BarkerThe Institute for Systems Biology, Seattle
Publication Date2005/2005
Bibliographic Information
465 pp., illus., appendices, index
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Related Products At the Bench: A Laboratory Navigator
At the Helm: A Laboratory Navigator

Title   At the Helm: Leading Your Laboratory, Second Edition
Unique URL   http://www.cshlpress.com/link/at_helm2.htm
ISBN978-0-879698-66-9
Price$61.00
Series Information: 
Since 2002, the first edition of this best-selling book has helped thousands of newly appointed principal investigators successfully transition to running their own labs. But changes in technology continue to transform the way science is done, affecting ways in which labs communicate and collaborate, organize data and supplies, and keep current on the latest developments. The culture of science has also evolved, as more scientists explore non-academic career paths, seek new ways to communicate information and ideas, and acquire skills and knowledge outside of their field. In the second edition of this book, Kathy Barker has substantially revised the text, offering PIs advice on adapting to the changes and challenges that the years have brought. New topics include collaboration contracts, performance evaluations, communicating with non-scientists, tips for succeeding on the tenure track, and professional development. With this book as a guide, any new or aspiring PI will be well-equipped to manage personnel, time, and institutional responsibilities with confidence.

About the author: Kathy Barker received her B.A. in Biology and English, and her M.A. and Ph.D. in Microbiology, from various branches of the University of Massachusetts. She did her postdoctoral work in the laboratory of Viral Oncology at Rockefeller University and was an Assistant Professor in the Laboratory of Cell Physiology and Immunology at Rockefeller University. She is now based in Seattle, where she writes and gives workshops on various aspects of running a lab.



Dr. Barker invites you to send any comments or questions to her.

Author
  Kathy BarkerSeattle, Washington
Publication Date2010/2010
Bibliographic Information
372 pp., illus. (2 b/w), index
Trim size: 7” x 10”
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At the Bench: A Laboratory Navigator, Updated Edition

Title   Auxin Signaling: From Synthesis to Systems Biology
Unique URL   http://www.cshlpress.com/link/auxinsig.htm
ISBN978-0-879698-98-0
Price$135
Series Information: 

Auxin is an important plant hormone that controls numerous aspects of development and physiology, including responses to light, tissue patterning, and organogenesis. It forms concentration gradients across various tissues throughout the plant and exerts its effects by binding to auxin binding proteins and regulating transcription of distinct sets of target genes.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology describes the numerous processes auxin controls. These include growth of the shoot apical meristem, leaf and vein patterning, and flower, fruit, and root development. Other chapters examine how auxin is synthesized by plants, the nature of auxin receptors, the Aux/IAA family of transcriptional repressors that auxin regulates, and the variety of auxin transport mechanisms that exist in plants.


The book also examines the extraordinary complexity of auxin responses and discusses new computational models for mechanisms that allow this hormone to generate such a wide variety of outputs. It is thus of interest to systems biologists, biochemists, and developmental biologists, as well as all plant biologists interested in the regulation of plant behavior and morphogenesis.



Editor
  Mark EstelleUniversity of California, San Diego
Publication Date2011/2011
Bibliographic Information
253 pp., illus. (36 color, 13 b/w), index

Trim size: 7” x 10”
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Title   Bacterial Pathogenesis
Unique URL   http://www.cshlpress.com/link/bacterialpath.htm
ISBN978-1-936113-36-1
Price$135
Series Information: 

Bacterial pathogens cause numerous human diseases. This collection from Cold Spring Harbor Perspectives in Medicine surveys the spectrum of bacterial pathogens from Salmonella and Shigella to Heliobacter pylori. It examines the basic biology of these parasites, their virulence mechanisms and the host’s response to infection. The effectiveness of antibiotics and vaccine strategies are also covered, along with the novel antimicrobial therapies that are being developed.


Editor
  Stanley MaloySan Diego State University
Publication Date2014/2014
Bibliographic Information
413 pp., illus., index
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Title   Basic Methods in Microscopy
Protocols and Concepts from Cells: A Laboratory Manual

Unique URL   http://www.cshlpress.com/link/basmicp.htm
ISBN978-087969751-8
Price$97.00
Series Information: 
Imaging has become a vital tool for researchers in all aspects of biology. Recent advances in microscope technology, labeling techniques and gene and protein manipulation methods have led to breakthroughs in our understanding of biological processes. In order to take advantage of these techniques, biologists need to understand the fundamental techniques of microscopy. The methods found here, drawn from the popular laboratory standard manual Cells: A Laboratory Manual, provide a solid course in the basics of using the microscope in a biology laboratory.

Basic Methods in Microscopy provides an essential guide to light microscopy, fluorescence microscopy, confocal microscopy, multiphoton microscopy and electron microscopy, preparation of tissues and cells, labeling of specimens and analysis of cellular events.

This manual is an important tool for any biology researcher employing imaging as a research method.

Author
  David L. SpectorCold Spring Harbor Laboratory
Publication Date2006/2006
Bibliographic Information
382 pp., illus., index
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Related Products Basic Methods in Microscopy
Protocols and Concepts from Cells: A Laboratory Manual


Title   Basic Methods in Protein Purification and Analysis: A Laboratory Manual
Unique URL   http://www.cshlpress.com/link/bmppa.htm
ISBN978-087969868-3
Price$162.00
Series Information: 
Understanding how proteins function is an essential part of many biological research endeavors. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. The latest manual in the Basic Methods series contains a collection of convenient and easy to use protein purification protocols along with a sampling of dependable methods for assessing protein–protein interactions. The protocols are supported by background information to assist researchers in understanding how the purification methods work and how to optimize and troubleshoot the methods.

The collection of essential methods found in Basic Methods in Protein Purification and Analysis is mainly drawn from the popular manuals Proteins and Proteomics, Purifying Proteins for Proteomics, and Protein–Protein Interactions, 2nd Ed. In addition to protocols for purification using gel electrophoresis and column chromatography, this book contains tested methods for preparing cellular and subcellular extracts—a critical and often neglected step in successful protein purification. Rounding out the manual are methods for characterizing protein–protein interactions, an extensive appendix of essential methods for quantifying protein concentration, stabilizing and storing proteins, concentrating proteins, and immunoblotting. Finally, there is a new chapter on a method complementary to gel electrophoresis and chromatography: in silico analysis of genomic and proteomic databases.

Editor
  Richard J. SimpsonJoint ProteomicS Laboratory (JPSL) of the Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Publication Date2009/2009
Bibliographic Information
436 pp., illus., appendices, index
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Related Products Basic Methods in Protein Purification and Analysis: A Laboratory Manual
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Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition
Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition

Title   Basic Methods in Protein Purification and Analysis: A Laboratory Manual
Unique URL   http://www.cshlpress.com/link/bmppap.htm
ISBN978-087969-867-6
Price$97
Series Information: 
Understanding how proteins function is an essential part of many biological research endeavors. The complexity and sheer number of proteins in a cell are impediments to identifying proteins of interest or purifying proteins for function and structure analysis. Thus, reducing the complexity of a protein sample or in some cases purifying a protein to homogeneity is necessary. The latest manual in the Basic Methods series contains a collection of convenient and easy to use protein purification protocols along with a sampling of dependable methods for assessing protein–protein interactions. The protocols are supported by background information to assist researchers in understanding how the purification methods work and how to optimize and troubleshoot the methods.

The collection of essential methods found in Basic Methods in Protein Purification and Analysis is mainly drawn from the popular manuals Proteins and Proteomics, Purifying Proteins for Proteomics, and Protein–Protein Interactions, 2nd Ed. In addition to protocols for purification using gel electrophoresis and column chromatography, this book contains tested methods for preparing cellular and subcellular extracts—a critical and often neglected step in successful protein purification. Rounding out the manual are methods for characterizing protein–protein interactions, an extensive appendix of essential methods for quantifying protein concentration, stabilizing and storing proteins, concentrating proteins, and immunoblotting. Finally, there is a new chapter on a method complementary to gel electrophoresis and chromatography: in silico analysis of genomic and proteomic databases.

Editor
  Richard J. SimpsonJoint ProteomicS Laboratory (JPSL) of the Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Publication Date2009/2009
Bibliographic Information
436 pp., illus., appendices, index
Set Info
Topics
Related Products Basic Methods in Protein Purification and Analysis: A Laboratory Manual
Proteins and Proteomics: A Laboratory Manual
Proteins and Proteomics: A Laboratory Manual
Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition
Protein-Protein Interactions: A Molecular Cloning Manual, Second Edition

Title   Basic Stereology for Biologists and Neuroscientists
Unique URL   http://www.cshlpress.com/link/basicstereo.htm
ISBN978-1-936113-60-6
Price$69
Series Information: 

Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two-dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain.


This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phenomena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture.


Author
  Mark J. WestUniversity of Aarhus, Denmark
Publication Date2012/2012
Bibliographic Information
206 pp., illus., index
Set Info
Topics

Title   A Bioinformatics Guide for Molecular Biologists
Unique URL   http://www.cshlpress.com/link/bioinfoguidemb.htm
ISBN978-1-936113-22-4
Price$79
Series Information: 

Informatics can vastly assist progress in research and development in cell and molecular biology and biomedicine. However, many investigators are either unaware of the ways in which informatics can improve their research or find it inaccessible due to a feeling of “informatics anxiety.” This sense of apprehension results from improper communication of the principles behind these approaches and of the value of the many tools available. In fact, many researchers are inherently distrustful of these tools. A more complete understanding of bioinformatics offered in A Bioinformatics Guide for Molecular Biologists will allow the reader to become comfortable with these techniques, encouraging their use—thus helping to make sense of the vast accumulation of data. To make these concepts more accessible, the editors approach the field of bioinformatics from the viewpoint of a molecular biologist, (1) arming the biologist with a basic understanding of the fundamental concepts in the field, (2) presenting approaches for using the tools from the standpoint of the data for which they are created, and (3) showing how the field of informatics is quickly adapting to the advancements in biology and biomedical technologies. All concepts are paired with recommendations for the appropriate programming environment and tools best suited to solve the particular problem at hand. It is a must-read for those interested in learning informatics techniques required for successful research and development in the laboratory.

Editor
  Sarah AerniPivotal Software, Inc.
Publication Date2014/2014
Bibliographic Information
328 pp, illus. (64 4C, 26 B&W), index
Set Info
Topics

Title   Bioinformatics: Sequence and Genome Analysis, Second Edition
Unique URL   http://www.cshlpress.com/link/bioinf2p.htm
ISBN978-087969712-9
Price$95
Series Information: 

As more species’ genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.

Author
  David MountUniversity of Arizona, Tucson
Publication Date2004/2004
Bibliographic Information
665 pp., illus., appendices, index
Set Info
Topics
Related Products Bioinformatics: Sequence and Genome Analysis, Second Edition

Title   The Biological Revolution: 100 Years of Science at Cold Spring Harbor
Unique URL   http://www.cshlpress.com/link/biol_rev.htm
ISBN978-087969991-8
Price$19.95
Series Information: 


The Biological Revolution: 100 Years of Science at Cold Spring Harbor,
a 30-minute video documentary providing the nonscientist with a
cogent explanation of the origins of the DNA revolution that is now
sweeping the country, is invaluable teaching material for junior and
senior high school classes.




Using Cold Spring Harbor Laboratory as a case study, the video
shows the parallel development of American science and society, while
providing a first-hand account of the development of modern genetics.
Through events that have occurred at Cold Spring Harbor, the video
documents the quest to understand the nature of the genetic code,
beginning with Darwin's theory of evolution and culminating with
powerful techniques to precisely manipulate the DNA molecule.




Laboratory Director James Watson, who shared the Nobel Prize for
elucidating the double-helix structure of DNA, serves as on-site host.
He and four other Nobel laureates-Alfred Hershey, Salvador Luria,
Barbara McClintock, and Walter Gilbert-lend their own insights on
the genetic revolution they helped launch.




Viewers are brought up-to-the-minute on how recombinant DNA techniques
are being employed in the wars against cancer and world hunger.
Included is stunning footage which shows cancer-causing proteins
being injected directly into living cells using a needle with a tip
1/100th the diameter of a human hair.

Publication DateJANUARY 1989/1986
Bibliographic Information
30-minute video
Set Info
Topics

Title   The Biology of Alzheimer Disease
Unique URL   http://www.cshlpress.com/link/bioalzdis.htm
ISBN978-1-936113-44-6
Price$135
Series Information: 

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progresses—including the accumulation of amyloid plaques and neurofibrillary tangles—is critical for the development of successful therapeutic approaches.



Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid β-protein precursor (APP), tau, presenilin, β-secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis.



This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.


Editor
  Dennis J. SelkoeHarvard Medical School
Publication DateDecember 2011/2011
Bibliographic Information
511 pp., illus. (63 4C & 9 B&W), index
Set Info
Topics

Title   Biology of Drosophila
Unique URL   http://www.cshlpress.com/link/biodrosp.htm
ISBN978-087969828-7
Price$42.00
Series Information: 

Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.


Editor
  M. Demerec
Publication Date2008/2008
Bibliographic Information
632 pp., illus., indexes
Set Info
Topics
Related Products Biology of Drosophila

Title   Biology of Heart Disease
Unique URL   http://www.cshlpress.com/link/bioheartdis.htm
ISBN978-1-936113-86-6
Price$135
Series Information: 

The heart is the first organ to form in a developing embryo, and all subsequent life processes depend on its proper function. But a range of genetic and environmental factors can lead to its failure. Inherited mutations give rise to congenital heart disease, the most common birth defect, and abnormalities of the adult heart are a leading cause of illness and death in industrialized countries.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine describes how recent advances in genetics, stem cell biology, and developmental biology are transforming the way we understand and treat heart disease. Contributors review the various cell lineages and molecular networks involved in heart development; the genetic basis of inherited cardiac conditions such as congenital heart disease, cardiomyopathies, and aortic aneurysm; and how various cutting-edge technologies and models are being employed to study heart biology, uncover disease-related processes, and identify therapeutic targets. Topics include tissue engineering, genome editing, stem cells, cardiomyocyte reprogramming, chemically modified RNA, and next-generation DNA sequencing.


The authors also consider the process of drug discovery and development, and the potential for patient-specific treatments and therapies. This volume is a valuable reference for cardiologists, geneticists, and cell and developmental biologists interested in this complex, vital organ and the future of cardiovascular medicine.


Editor
  Kenneth R. ChienMassachusetts General Hospital
Publication DateNovember 2014/2014
Bibliographic Information
320 pp. (approx.), illus. (47 4C, 3 B&W), index
Set Info
Topics

Title   The Biology of Plants
Unique URL   http://www.cshlpress.com/link/symp-77.htm
ISBN978-1-621820-25-3
Price$318
Series Information: 

Plants are integral to human wellbeing, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts from cultures around the world (Chinese, Indian, Greco-Roman, Muslim etc.), while early modern botany can be traced to the late 15th and early 16th centuries in Europe. During the past several decades plant biology has been revolutionized first by molecular biology and then by the genomic era. The model organism Arabidopsis thaliana has proved an invaluable tool for investigation into fundamental processes in plant biology, many of which share commonalities with animal biology. Plant-specific processes from reproduction to immunity and second messengers have also yielded to extensive investigation. With the genomes of more than thirty plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflects the enormous research progress achieved in recent years, and is intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series focused exclusively on the botanical sciences.


Editor
  Terri GrodzickerCold Spring Harbor Laboratory
Publication Date2013/2013
Bibliographic Information
352 pp., illus. 55 4C, 102 B
Set Info
Topics
Related Products The Biology of Plants

Title   The Biology of Plants
Unique URL   http://www.cshlpress.com/link/symp-77p.htm
ISBN978-1-621820-26-0
Price$129
Series Information: 

Plants are integral to human wellbeing, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts from cultures around the world (Chinese, Indian, Greco-Roman, Muslim etc.), while early modern botany can be traced to the late 15th and early 16th centuries in Europe. During the past several decades plant biology has been revolutionized first by molecular biology and then by the genomic era. The model organism Arabidopsis thaliana has proved an invaluable tool for investigation into fundamental processes in plant biology, many of which share commonalities with animal biology. Plant-specific processes from reproduction to immunity and second messengers have also yielded to extensive investigation. With the genomes of more than thirty plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflects the enormous research progress achieved in recent years, and is intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series focused exclusively on the botanical sciences.


Editor
  Terri GrodzickerCold Spring Harbor Laboratory
Publication Date2013/2013
Bibliographic Information
352 pp., illus. 55 4C, 102 B
Set Info
Topics
Related Products The Biology of Plants

Title   Blue Skies and Bench Space: Adventures in Cancer Research
Unique URL   http://www.cshlpress.com/link/blueskies.htm
ISBN978-1-621820-77-2
Price$22
Series Information: 

What happens when a cancer research institute’s only remit is to be the best it can be? For more than 100 years, one laboratory in London has operated on just that premise. With a generous budget, inspired leadership, and a stable of scientific thoroughbreds, the Imperial Cancer Research Fund Laboratories produced some of the 20th century’s most exciting advances in molecular biology. In its 21st century incarnation, as the Cancer Research UK London Research Institute, it continues to inspire a new generation of researchers.


In this book, written with the assistance of the past and present inhabitants of the London Research Institute, Kathy Weston tells the inside story of the lab’s greatest voyages into the scientific unknown, revealing the personalities behind the dry passive voice of the scientific paper. Science is an art, a vocation, a complicated landscape of data in which, just sometimes, the trained and alert eye can detect a glint of gold. In these pages, the gold is present, but equally to be treasured are the all-too-human scientists stumbling towards its seductive glimmer.

Author
  Kathleen WestonCancer Research UK London Research Institute
Publication Date2014/2014
Bibliographic Information
336 pp., illus., glossary, index
Set Info
Topics

Title   C. elegans Atlas
Unique URL   http://www.cshlpress.com/link/celatlash.htm
ISBN978-087969794-5
Price$179.00
Series Information: 
Derived from the acclaimed online “WormAtlas,” C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm” by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
Author
  David H. HallAlbert Einstein College of Medicine, New York
Publication Date2008/2008
Bibliographic Information
348 pp., illus., appendix, index
Set Info
Topics
Related Products C. elegans Atlas
The Nematode Caenorhabditis elegans
C. elegans II

Title   C. elegans Atlas
Unique URL   http://www.cshlpress.com/link/celatlas.htm
ISBN978-087969715-0
Price$128.00
Series Information: 
Derived from the acclaimed online “WormAtlas,” C. elegans Atlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm” by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegans II monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
Author
  David H. HallAlbert Einstein College of Medicine, New York
Publication Date2008/2008
Bibliographic Information
348 pp., illus., appendix, index
Set Info
Topics
Related Products C. elegans Atlas
The Nematode Caenorhabditis elegans
C. elegans II

Title   C. elegans II
Unique URL   http://www.cshlpress.com/link/celegans.htm
ISBN978-087969532-3
Price$75
Series Information: 
Studies of the cells and genes of the nematode C. elegans have
become a cornerstone of current biology. A classic 1988 Cold Spring
Harbor monograph,
The Nematode Caenorhabditis elegans,
described the basic genetics, anatomy and development
of the organism. Now, in that authoritative tradition, comes C. elegans
II
-- not a second edition but a book that breaks new ground and defines
the current status of the field, providing a detailed molecular
explanation of how development is regulated and the nervous system
specifies varied aspects of behavior. This volume is a must for any
investigator doing worm studies but it has been written and rigorously
edited to illuminate for a wider community of investigators in cell
and molecular biology who should know how new knowledge of C. elegans
relates to their own specialty.

Editor
  Donald L. RiddleUniversity of Missouri, Columbia
Publication DateFebruary 1997/1997
Bibliographic Information
1222 pp., illus., color plates, index
Set Info
Topics
Related Products The Nematode Caenorhabditis elegans
C. elegans Atlas

Title   Calcium Signaling
Unique URL   http://www.cshlpress.com/link/calciumsig.htm
ISBN978-0-87969-903-1
Price$135
Series Information: 

Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. They can enter the cytoplasm from the extracellular environment or from intracellular stores and control the activity of numerous enzymes, other signaling molecules, transcription factors, and cytoskeletal components.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores the channels and pumps that transport calcium between different compartments and the regulation of calcium fluxes. The contributors discuss calcium buffers and sensors and how these produce distinct spatiotemporal calcium signals in different circumstances.


Including discussions of calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis, the volume is an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium biology.

Editor
  Martin D. BootmanThe Babraham Institute
Publication Date2011/2011
Bibliographic Information
499 pp., illus. (71 4C color images and 11 B&W images), index
Set Info
Topics

Title   Calcium Techniques: A Laboratory Manual
Unique URL   http://www.cshlpress.com/link/calciumtech.htm
ISBN978-1-621820-78-9
Price$150
Series Information: 

Life begins with a surge of calcium ions (Ca2+) at fertilization, and thereafter, Ca2+ signaling influences nearly every aspect of mammalian development and physiology, from gene expression and cell proliferation to muscle contraction and nerve impulses. To create spatiotemporally distinct Ca2+ signals, cells use a variety of mechanisms to recognize, transport, and buffer Ca2+. Thus, a diverse range of reliable experimental techniques is necessary to study the movement of Ca2+ and the various effectors involved.


This laboratory manual provides step-by-step protocols for studying many facets of Ca2+ signaling, as well as background information on the principles and applications of the techniques. Contributors discuss how to use fluorescent, luminescent, and genetically encoded Ca2+ probes in conjunction with state-of-the-art imaging modalities to characterize Ca2+ signals. Electrophysiological measurements of Ca2+ channel activity are described, as are radioactive Ca2+ flux assays and methods to investigate signaling mediated by specific Ca2+-mobilizing messengers (IP3, cADPR, and NAADP). Techniques to modulate and suppress intra- and intercellular signals are also provided. Each protocol is complete with a list of required materials, detailed recipes for media and reagents, and troubleshooting advice.


Specific chapters are devoted to Ca2+ signaling techniques in nonmammalian systems, such as plants, yeast, zebrafish, and Xenopus. Methods for assessing Ca2+-binding kinetics and strategies for developing mathematical models of Ca2+ signaling are also included. Thus, this manual is a comprehensive laboratory resource for biochemists, cell and developmental biologists, and physiologists who are using or looking to expand their repertoire of Ca2+ techniques.


Editor
  Jan B. ParysKU Leuven
Publication Date2014/2014
Bibliographic Information
608 pp., illus. (62 4C, 56 B&W), index
Set Info
Topics

Title   Calcium Techniques: A Laboratory Manual
Unique URL   http://www.cshlpress.com/link/calciumtechp.htm
ISBN978-1-936113-58-3
Price$95
Series Information: 

Life begins with a surge of calcium ions (Ca2+) at fertilization, and thereafter, Ca2+ signaling influences nearly every aspect of mammalian development and physiology, from gene expression and cell proliferation to muscle contraction and nerve impulses. To create spatiotemporally distinct Ca2+ signals, cells use a variety of mechanisms to recognize, transport, and buffer Ca2+. Thus, a diverse range of reliable experimental techniques is necessary to study the movement of Ca2+ and the various effectors involved.


This laboratory manual provides step-by-step protocols for studying many facets of Ca2+ signaling, as well as background information on the principles and applications of the techniques. Contributors discuss how to use fluorescent, luminescent, and genetically encoded Ca2+ probes in conjunction with state-of-the-art imaging modalities to characterize Ca2+ signals. Electrophysiological measurements of Ca2+ channel activity are described, as are radioactive Ca2+ flux assays and methods to investigate signaling mediated by specific Ca2+-mobilizing messengers (IP3, cADPR, and NAADP). Techniques to modulate and suppress intra- and intercellular signals are also provided. Each protocol is complete with a list of required materials, detailed recipes for media and reagents, and troubleshooting advice.


Specific chapters are devoted to Ca2+ signaling techniques in nonmammalian systems, such as plants, yeast, zebrafish, and Xenopus. Methods for assessing Ca2+-binding kinetics and strategies for developing mathematical models of Ca2+ signaling are also included. Thus, this manual is a comprehensive laboratory resource for biochemists, cell and developmental biologists, and physiologists who are using or looking to expand their repertoire of Ca2+ techniques.

Editor
  Jan B. ParysKU Leuven
Publication Date2014/2014
Bibliographic Information
608 pp., illus. (62 4C, 56 B&W), index
Set Info
Topics

Title   Career Opportunities in Biotechnology and Drug Development
Unique URL   http://www.cshlpress.com/link/careerp.htm
ISBN978-0-879698-80-5
Price$40.00
Series Information: 

As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the door? What will your job entail if you become a “Preclinical Project Manager” or a “Process Scientist”? What’s the difference between biotech and pharma?

Career Opportunities in Biotechnology and Drug Development provides a comprehensive and systematic overview of careers in the life science industry, with all their ups and downs. The author, Toby Freedman, Ph.D., has conducted interviews with hundreds of key players in the industry, who provide first–hand explanations of their day–to–day roles and responsibilities, and offer key insights into how they landed those jobs in the first place. Careers in everything from discovery research to venture capital are covered in detail.

Each chapter includes valuable sections on preparing yourself for a prospective career: educational requirements and personality characteristics needed; recommendations of books, magazines, and Web site resources; and issues to consider regarding salary and compensation. The book also includes interviewing and job searching tips, as well as suggestions on writing a resume specifically for industry.

Career Opportunities in Biotechnology and Drug Development is an essential guide for science graduates and medical, business, legal, high–tech or engineering professionals. With discussions of job security, future trends, and potential career paths, even those already working in industry will find helpful information on how to take advantage of opportunities available within their own companies and elsewhere. This book will help you make wiser and more informed decisions about what role you would like to play in the biotechnology and drug development industry.
Author
  Toby FreedmanSynapsis Search, Portola Valley, California
Publication Date2009/2009
Bibliographic Information
409 pp., illus., index
Set Info
Topics
Related Products Career Opportunities in Biotechnology and Drug Development
At the Helm: A Laboratory Navigator

Title   Career Options for Biomedical Scientists
Unique URL   http://www.cshlpress.com/link/CareerOpsBioSci.htm
ISBN978-1-936113-72-9
Price$45
Series Information: 
The majority of PhDs trained in biomedical sciences do not remain in academia. They are now presented with a broad variety of career options, including science journalism, publishing, science policy, patent law, and many more. This book examines the numerous different careers that scientists leaving the bench can pursue, from the perspectives of individuals who have successfully made the transition. In each case, the book sets out what the job involves and describes the qualifications and skills sets required.
Editor
  Kaaren JanssenCold Spring Harbor Laboratory Press
Publication DateOctober 2014/2014
Bibliographic Information
232pp., illus. (3 4C, 26 B&W), index

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Title   Cell Biology of Addiction
Unique URL   http://www.cshlpress.com/link/celbioad.htm
ISBN978-087969753-2
Price$129
Series Information: 
This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.
Editor
  Bertha K. MadrasHarvard Medical School
Publication Date2006/2006
Bibliographic Information
465 pp., illus., appendices, index
Set Info
Topics

Title   Cell Growth: Control of Cell Size
Unique URL   http://www.cshlpress.com/link/cellgrow.htm
ISBN978-087969672-6
Price$139
Series Information: 
Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook.
Editor
  Michael N. HallBiozentrum, University of Basel
Publication Date2004/2004
Bibliographic Information
652 pp., illus., appendices, index
Set Info
Topics

Title   Cell Survival and Cell Death
Unique URL   http://www.cshlpress.com/link/cellsurdeath.htm
ISBN978-1-936113-31-6
Price$135
Series Information: 

Billions of cells die every day in the human body. This is required for normal development and physiology, as well as the elimination of errant cells. Apoptosis and other cell death mechanisms are complex and carefully controlled. If cell death does not occur when it should, cancer and other diseases may develop.


Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of apoptosis, autophagy, and necrosis. Contributors describe in detail the molecular mechanisms of cell death signaling, including death receptor-ligand systems, BCL-2 family proteins, mitochondrial permeabilization, the endocytic pathway, caspases, and signals that trigger the clearance of dying cells. Survival mechanisms and proteins such as IAPs that antagonize cell death are also described.


This volume includes discussion of tumor suppression, the altered metabolism of cancer cells, and the development of therapeutic drugs. It is an essential reference for cell and developmental biologists, cancer biologists, and all who want to understand when and how cell death is required for life.


Editor
  Eric H. BaehreckeUniversity of Massachusetts
Publication Date2013/2013
Bibliographic Information
380 pp., illus. (59 4C, 25 B&W), index
Set Info
Topics

Title   Cell-Cell Junctions
Unique URL   http://www.cshlpress.com/link/cellcelljunc.htm
ISBN978-0-879698-84-3
Price$135
Series Information: 
Cell-cell junctions are multi-molecular complexes that link neighboring cells. They help maintain tissue integrity, act as barriers to permeability, and allow intercellular transport. They also reinforce cell polarity by separating the apical and basolateral domains of the plasma membrane.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering each of the main junction types—tight junctions, adherens junctions, and desmosomes—as well as the more specialized junctions of neuronal and immune cells. The contributors examine the assembly and structure of different cell junctions, their roles in cellular signal transduction, and their importance during development and normal tissue homeostasis.


Including discussion of the roles of junctions in various diseases, this volume is a vital reference for cell and developmental biologists wishing to know how cells interact in multicellular organisms.

Editor
  W. James NelsonStanford University
Publication Date2010/2010
Bibliographic Information
443 pp., illus., index
Set Info
Topics

Title   Clocks and Rhythms
Unique URL   http://www.cshlpress.com/link/clocks.htm
ISBN978-087969822-5
Price$310
Series Information: 
Based on presentations by world-renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.
Editor
  Bruce StillmanCold Spring Harbor Laboratory
Publication Date2007/2007
Bibliographic Information
674 pp., illus., indexes
Set Info
Topics
Related Products Clocks and Rhythms

Title   The Coiled Spring: How Life Begins
Unique URL   http://www.cshlpress.com/link/coiledspring.htm
ISBN978-087969562-0
Price$62
Series Information: 


A concise, readable account of the principles underlying embryonic
and appendage development in animals and plants, illustrated with
colorful artwork and interviews with prominent investigators.
Highly recommended for use in undergraduate and graduate courses.

Author
  Ethan BierUniversity of California, San Diego
Contributor
  Cliff TabinHarvard Medical School
Publication DateAugust 2000/2000
Bibliographic Information
252 pp., illus., color plates, index, glossary,
bibliography
Set Info
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Related Products The Coiled Spring: How Life Begins

Title   Cold Spring Harbor Monograph Archive
Unique URL   not available
ISBN978-087969-941-3
Price$3000
Series Information: 
The Cold Spring Harbor Monograph Archive is the complete collection of scholarly monographs published by Cold Spring Harbor Laboratory Press from 1970 to 2009. The archive's 59 full-text volumes provide the life science community with definitive reviews of progress in areas of molecular, cell, and developmental biology, genetics, evolutionary biology, neuroscience, cancer biology, and molecular pathology. Each text is written and commissioned by foremost researchers in their particular discipline.

The archive is an unmatched resource for its breadth of coverage in key topics and provides an in-depth account of developments as they occurred in numerous fields
Publication DateOctober/2009
Bibliographic Information
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Title   Concerning the Origin of Malignant Tumours
Unique URL   http://www.cshlpress.com/link/cnorgtmr.htm
ISBN978-087969788-4
Price$25.00
Series Information: 

An English translation of Boveri’s famous monograph which was first
published in Germany in 1914.

Written almost a hundred years ago,
Theodor Boveri’s Zur Frage der Entstehung maligner Tumoren has had a
momentous impact on cancer research. In it he argues that malignancy
arises as a consequence of chromosomal abnormalities and that
multiplication is an inherent property of cells. With astonishing
prescience, Boveri predicts in this monograph the existence of tumor
suppressor mechanisms and is perhaps the first to suggest that
hereditary factors (genes) are linearly arranged along chromosomes. This
new translation by Sir Henry Harris, Regius Professor of Medicine
Emeritus at Oxford University and former Editor-in-Chief of Journal of
Cell Science,
includes extensive annotations in which he discusses the
relevance of Boveri’s views today. It is essential reading for all
cancer researchers, as well as those interested in the history of
cytogenetics and cell biology.

Author
  Theodor Boveri
Publication Date2008/2008
Bibliographic Information
82 pp.
Set Info
Topics
Related Products The Cells of the Body: A History of Somatic Cell Genetics

Title   Connecting with Companies: A Guide to Consulting Agreements for Biomedical Scientists
Unique URL   http://www.cshlpress.com/link/ConnectwComp.htm
ISBN978-1-621821-07-6
Price$39
Series Information: 

An essential guide for academic scientists and physicians who are considering consulting work in biomedicine




Before signing a consulting agreement, this must-have reference will help you understand the key issues to consider—from intellectual property, confidentiality, and compensation, to often overlooked issues such as indemnity, different classes of stock, and the relevance of insider trading and securities laws. 


Read Connecting with Companies and you will:


  • Gain invaluable, first-hand advice from the authors: a leading attorney and a Nobel Laureate in Physiology or Medicine, both with extensive experience reviewing and negotiating consulting agreements

  • Receive guidance for academics, lawyers, accountants, auditors, venture capitalists, and technology transfer departments of universities, hospitals, and research organizations

  • Understand crucial start-up issues such as 83b tax election and participating preferred stock


  • For more information visit Bioagreements.org


    Connecting with Companies is an invaluable resource for students, staff, and faculty. To assist you with ordering multiple copies for your institution, we’ve set up the following discount options:


Author
  Edward Klees, J.D.General Counsel at the University of Virginia Investment Management Company
Publication Date2014/2014
Bibliographic Information
156 pp., glossary, index

Buy 10-19 copies—30% off



Buy 20-29 copies—35% off


Buy 30 or more copies—40% off

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Topics

Title   Control and Regulation of Stem Cells
Unique URL   http://www.cshlpress.com/link/conregstem.htm
ISBN978-087969861-4
Price$310
Series Information: 
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer.

Editor
  Terri GrodzickerCold Spring Harbor Laboratory
Publication Date2008/2008
Bibliographic Information
614 pp., illus., indexes
Set Info
Topics
Related Products Control and Regulation of Stem Cells
Stem Cell Biology
Stem Cell Biology

Title   Control and Regulation of Stem Cells
Unique URL   http://www.cshlpress.com/link/conregstemp.htm
ISBN978-087969862-1
Price$126
Series Information: 
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer.
Editor
  Terri GrodzickerCold Spring Harbor Laboratory
Publication Date2008/2008
Bibliographic Information
614 pp., illus., indexes
Set Info
Topics
Related Products Control and Regulation of Stem Cells
Stem Cell Biology
Stem Cell Biology

Title   Correcting the Blueprint of Life: An Historical Account of the Discovery of DNA Repair Mechanisms
Unique URL   http://www.cshlpress.com/link/corblu.htm
ISBN978-087969507-1
Price$27
Series Information: 


In this brief, readable, and revealing book, one of the pioneers
of the now rapidly evolving field of DNA repair traces the history of
the discovery of the more important mechanisms by which cells respond
to DNA damage. Errol Friedberg has written an enjoyable and informative
introduction to the study of DNA mutagenesis and re-pair that will
interest students at an advanced undergraduate or graduate student
level as well as investigators in fields as diverse as oncogenesis,
cell cycle regulation, transcription and DNA replication.

  Errol C. FriedbergThe University of Texas Southwestern
Publication DateJune 1997/1997
Bibliographic Information
210 pp., illus., index
Set Info
Topics

Title   CSH Symposia Online Archive
Unique URL   not available
ISBN978-087969-860-7
Price$3000.00
Series Information: 


The double helix, the genetic code, jumping genes, the PCR technique, the human genome project, RNA interference ...
These and hundreds of other important advances in biology were announced, debated, and distilled at the Cold Spring Harbor
Symposia. These meetings, held each year on tranquil grounds of one of the world's leading research institutes,
have been notable events in biomedical research since 1933.




Now this essential archive, dating from 1933 to 2003, is going online. Learn more about the CSH Symposia Online Archive by visiting the Symposia website.


    Publication DateOctober /2008
    Bibliographic Information
    Set Info
    Topics

    Title   Cystic Fibrosis: A Trilogy of Biochemistry, Physiology, and Therapy
    Unique URL   http://www.cshlpress.com/link/cysticfibrosis.htm
    ISBN978-1-936113-34-7
    Price$135
    Series Information: 

    Cystic fibrosis is caused by mutations in the CFTR gene, which encodes an ion channel protein that regulates anion movement across the epithelial membranes of the lungs, pancreas, and other organs. In cystic fibrosis patients, anion transport is impeded, causing sticky, viscous mucus to build up and clog these vital organs.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides an in-depth examination of cystic fibrosis biology and treatment strategies. Contributors examine the structure and dynamics of CFTR, its normal physiological roles in the airway and digestive epithelia, and how those operations are impaired in patients with cystic fibrosis. The numerous CFTR mutations and how they alter the expression, synthesis, processing, and function of CFTR in cystic fibrosis and other CFTR-related disorders are considered, as are disease-modifying genes that influence disease severity.


    This volume includes discussions of therapy and treatment strategies for cystic fibrosis, ranging from airway clearance techniques and pancreatic enzyme replacements to the modulation of CFTR and related ion transport pathways. It will be an essential reference for molecular and cellular biologists, physiologists, and clinicians interested in understanding the biological basis of the disease and the search for effective therapies.


    Editor
      John R. RiordanThe University of North Carolina at Chapel Hill
    Publication Date2013/2013
    Bibliographic Information
    340 pp., illus. (40 4C; 15 B&W), index
    Set Info
    Topics

    Title   Davenport’s Dream: 21st Century Reflections on Heredity & Eugenics
    Unique URL   http://www.cshlpress.com/link/reread.htm
    ISBN978-087969756-3
    Price$55
    Series Information: 
    In 1911, the influential geneticist Charles Davenport published Heredity in Relation to Eugenics, advancing his ideas of how genetics would improve society in the 20th century. It became a college textbook and a foundation for the widespread eugenics movement in the United States. Nearly 100 years later, many of the issues raised by Davenport are again being debated, in different guises. In this new volume, prominent academics discuss themes from Davenport’s book—human genetic variation, mental illness, nature vs. nurture, human evolution—in a contemporary context. Davenport’s original book is reprinted along with the essays. This book will be useful to historians of science as well as those interested in the social implications of human genetics research—past, present, and future.
    Editor
      Jan A. WitkowskiCold Spring Harbor Laboratory
    Publication Date2008/2008
    Bibliographic Information
    490 pp., illus.
    Set Info
    Topics

    Title   The Dawn of Human Genetics
    Unique URL   http://www.cshlpress.com/link/dawnhumgen.htm
    ISBN978-1-936113-70-5
    Price$69
    Series Information: 
    In Russia, the initial euphoria of the Bolshevik leaders for a new socialist society ... combined with a commitment to a truly universal health care system, gave a huge boost to the emergence of both the eugenic and medical aspects of human genetics. The obstacles that proved so formidable to the successful launch of the field in the West—the lack of available data on the genealogy of diseases in families, the difficulty in getting a statistically significant number of identical twins to study, and the skepticism of the medical establishment—were all swept aside in the Soviet Union. In the 1920s ... the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world’s leading center for the study of the genetic basis of many diseases and human genetics in general. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov’s The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the “liquidation” of many of the country’s finest biologists, as well as a major setback to the development of world science. Like many other promising ideas and projects that were born in the Soviet Union, this one was abruptly truncated and then virtually eradicated.
    Author
      V.V. Babkov
    Editor
      James Schwartz
    Publication Date2013/2013
    Bibliographic Information
    775 pp., illus. (91 B&W ), index
    Set Info
    Topics

    Title   The Development of Drosophila melanogaster
    Unique URL   http://www.cshlpress.com/link/devdrosp.htm
    ISBN978-087969899-7
    Price$256.00
    Series Information: 
    The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
    Editor
      Michael BateUniversity of Cambridge
    Publication Date1993/1993
    Bibliographic Information
    1,564 pp. (2-volume set), illus., indexes
    Set Info
    Topics

    Title   The Development of Human Gene Therapy
    Unique URL   http://www.cshlpress.com/link/genthrpy.htm
    ISBN978-087969528-6
    Price$140
    Series Information: 


    The idea of human gene therapy was accepted by the medical community
    and society at large long before believable clinical benefits began
    to emerge. In this book, some of the field’s most distinguished
    contributors chronicle the evolution of this momentous direction for
    medicine, illustrating how imaginative concepts shaped the development
    of technologies and brought the daring new idea to its current position
    of imminent practical success. This is a book designed to endure as
    clinical advances accumulate, a clear-eyed work of reference that will
    anchor the further development of this revolution in therapy. It is an
    essential addition to libraries of clinical medicine, biotechnology,
    and public policy, and a resource that no laboratory investigator with
    an interest in the biology of gene transfer should be without.

    Editor
      Theodore FriedmannUniversity of California, San Diego
    Publication DateDecember 1998/1999
    Bibliographic Information
    729 pp., illus., color plates, index
    Set Info
    Topics
    Related Products Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual
    Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual

    Title   Discovering the Double Helix
    Unique URL   http://www.cshlpress.com/link/dblhelix.htm
    ISBN978-087969622-1
    Price$21
    Series Information: 


    The structure of DNA proposed by James Watson and Francis Crick in 1953 was one of the most important scientific discoveries of the twentieth century, transforming biology, giving medicine new impetus, and providing a foundation for the new industry of biotechnology. Jim Watson’s best-selling memoir of the events leading to this discovery, The Double Helix, has enthralled millions of readers since its publication in 1968. In this videotaped lecture, recorded live at Cold Spring Harbor Laboratory in November 1999, Dr. Watson retraces those events in a very personal reminiscence of the period and the people involved. This is an account of one of the great dramas of science, told from the intimate perspective of a participant who, aged 25 at the time of the discovery, has become one of the intellectual leaders of our time.



    James D. Watson was Director of Cold Spring Harbor Laboratory, New York, from 1968 to 1993 and is now its President. He was the first Director of the National Center for Human Genome Research of the National Institutes of Health from 1989 to 1992.



    Dr. Watson is a member of the National Academy of Sciences and Royal Society and has received many awards and honors, including the Presidential Medal of Freedom and the National Medal of Science. In addition to The Double Helix, his books include Molecular Biology of the Gene, Molecular Biology of the Cell, Recombinant DNA, and A Passion for DNA.

    Author
      James D. WatsonCold Spring Harbor Laboratory
    Publication DateOctober 2001/2001
    Bibliographic Information
    60-minute video
    Set Info
    Topics
    Related Products Discovering the Double Helix
    A Passion for DNA: Genes, Genomes, and Society
    A Passion for DNA: Genes, Genomes, and Society
    Winding Your Way Through DNA
    Winding Your Way Through DNA
    Houses for Science: A Pictorial History of Cold Spring Harbor Laboratory
    Stories from the Scientists
    Stories from the Scientists

    Title   DNA From The Beginning
    Unique URL   http://www.cshlpress.com/link/dnabegin.htm
    ISBN978-097105880-4
    Price$54.00
    Series Information: 

    DNA from the Beginning (a 3–CD set) is a multimedia primer on the basics of DNA, genes, and heredity. It is an ideal teaching tool for high school students and will also interest adults with a non-technical background who wish to learn more about the impact that DNA science is having on our lives.


    The content in DNA from the Beginning is built on a progressive series of important but simply stated concepts such as Children resemble their parents. An understanding of the concept is then conveyed in clear,understandable terms with the aid of links to animations, photographs, and video clips, and biographies or interviews featuring key scientists. A wealth of other information and links to web resources are included. Problems and their solutions are included to allow teaching through self-examination.


    Based on the award-winning web site, the DNA from the BeginningCD–ROM set provides over 72 hours of study time. It runs on Macintosh computers and PCs, and gives immediate access to all the online content, in attractive, uncluttered screens, without the need for network connections.


    A must for high schools and junior colleges in conjunction with biology classes.

    Editor
      David A. MicklosExecutive Editor
    Publication Date2002/2002
    Bibliographic Information
    3–CD–ROM set
    Set Info
    Topics

    Title   DNA Interactive DVD
    Unique URL   http://www.cshlpress.com/link/dnadvd.htm
    ISBN978-097105881-1
    Price$33.00
    Series Information: 

    “DNA has come a long way.” James D. Watson, Nobel Laureate



    DNA Interactive (DNAi) is a multimedia resource for high school and introductory college biology that shows how we came to understand the language of DNA, how we bend it to our own service, and what it can tell us about who we are. The DNAi products—an award winning website (http://www.dnai.org) and the DVD—are the result of a two–year collaboration between scientists, educators, and film–makers on three continents. It includes more than 200 video clips and animations; video interviews with 11 Nobel Laureates and more than 50 other scientists, clinicians, and patients; and spectacular 3–D animations that illustrate intracellular processes and explore aspects of DNA science.


     


     


     


     


     


     


     


     


     


     


     


     


     


     


     


     


     


     



    Producer
      Dolan DNA Learning Center, CSHL in collaboration with Red Green & Blue Company Ltd.
    Film footage by Windfall Films Ltd.
    Publication Date/2003
    Bibliographic Information
    DVD disc (NTSC version—unencoded), 4 hours (approx.) of viewing
    Set Info
    Topics

    Title   DNA Recombination
    Unique URL   http://www.cshlpress.com/link/dnarecomb.htm
    ISBN978-1-621820-09-3
    Price$135
    Series Information: 
    Recombination mechanisms allow cells to break and reattach DNA sequences. They are important for repair of damaged DNA. They also help generate additional genetic diversity in sperm and eggs cells by mixing DNA sequences from maternal and paternal chromosomes. This volume explores the molecular details of recombination and their roles in genome maintenance and meiosis.
    Editor
      Stephen Kowalczykowski, PhDUniversity of California, Davis
    Publication DateJanuary 2015/2014
    Bibliographic Information
    350 pp. (approx.), index
    Set Info
    Topics

    Title   DNA Repair, Mutagenesis, and Other Responses to DNA Damage
    Unique URL   http://www.cshlpress.com/link/dnarepair.htm
    ISBN978-1-936113-54-5
    Price$135
    Series Information: 

    Cellular DNA is constantly bombarded with environmental and chemical assaults that damage its molecular structure. In addition, the normal process of DNA replication is prone to error and may introduce mutations that can be passed to daughter cells. If left unrepaired, these DNA lesions can have serious consequences, such as cancer.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the mechanisms that cells use to recognize and repair various types of DNA damage. Contributors discuss base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, nonhomologous end joining, the SOS response, and other pathways in prokaryotes and eukaryotes, and describe how these processes are linked to DNA replication, transcription, and cell cycle controls. The repair of telomeric and mitochondrial DNA is described, as is the influence of chromatin structure on DNA repair.


    This volume also includes discussion of human genetic diseases that involve defects in DNA damage repair. It is an essential reference for molecular and cell biologists, medical geneticists, cancer biologists, and all who want to understand how cells maintain genomic integrity.


    Editor
      Errol C. FriedbergUniversity of Texas Southwestern Medical Center at Dallas
    Publication Date2014/2014
    Bibliographic Information
    445 pp., illus. (86 4C, 10 B&W), index
    Set Info
    Topics

    Title   DNA Replication
    Unique URL   http://www.cshlpress.com/link/dnareplication.htm
    ISBN978-1-936113-48-4
    Price$135
    Series Information: 

    DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands. Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed.


    Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life.


    Editor
      Stephen D. BellIndiana University, Bloomington
    Publication Date2013/2013
    Bibliographic Information
    576 pp., illus. (88 4C, 33 B&W), appendices, index
    Set Info
    Topics

    Title   DNA Replication and Human Disease
    Unique URL   http://www.cshlpress.com/link/dnarep2.htm
    ISBN978-087969766-2
    Price$139
    Series Information: 
    At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
    Editor
      Melvin L. DePamphilisNational Institutes of Health
    Publication Date2006/2006
    Bibliographic Information
    814 pp., illus., appendices, index
    Set Info
    Topics
    Related Products DNA Replication in Eukaryotic Cells

    Title   DNA Science: A First Course, Second Edition
    Unique URL   http://www.cshlpress.com/link/dnasci2p.htm
    ISBN978-1-936113-17-0
    Price$40.00
    Series Information: 

    This is the second edition of a highly successful textbook (over 50,000 copies sold) in which a highly illustrated, narrative text is combined with easy–to–use thoroughly reliable laboratory protocols. It contains a fully up–to–date collection of 12 rigorously tested and reliable lab experiments in molecular biology, developed at the internationally renowned Dolan DNA Learning Center of Cold Spring Harbor Laboratory, which culminate in the construction and cloning of a recombinant DNA molecule.



    Proven through more than 10 years of teaching at research and nonresearch colleges and universities, junior colleges, community colleges, and advanced biology programs in high school, this book has been successfully integrated into introductory biology, general biology, genetics, microbiology, cell biology, molecular genetics, and molecular biology courses.



    The first eight chapters have been completely revised, extensively rewritten, and updated. The new coverage extends to the completion of the draft sequence of the human genome and the enormous impact these and other sequence data are having on medicine, research, and our view of human evolution. All sections on the concepts and techniques of molecular biology have been updated to reflect the current state of laboratory research.



    The laboratory experiments cover basic techniques of gene isolation and analysis, honed by over 10 years of classroom use to be thoroughly reliable, even in the hands of teachers and students with no prior experience. Extensive prelab notes at the beginning of each experiment explain how to schedule and prepare, while flow charts and icons make the protocols easy to follow.



    As in the first edition of this book, the laboratory course is completely supported by quality–assured products from the Carolina Biological Supply Company, from bulk reagents, to useable reagent systems, to single–use kits, thus satisfying a broad range of teaching applications.

    Author
      David A. MicklosDolan DNA Learning Center, Cold Spring Harbor Laboratory
    Publication Date2003/2003
    Bibliographic Information
    575 pp., illus., appendices, index
    Set Info
    Topics
    Related Products Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes
    DNA Science: A First Course, Second Edition

    Title   Double Talking Helix Blues
    Unique URL   http://www.cshlpress.com/link/dbltalk.htm
    ISBN978-087969431-9
    Price$16
    Series Information: 

    "...the point of this story, I'll tell you right now.

    Did you ever sit down and think about how

    It is that each time a baby's born

    It's a baby -- not a rabbit or an ear of corn?"



    The answer is in DNA -- the stuff that genes are made of. Twin brothers
    Joel and Ira Herskowitz, physician and scientist, respectively, have
    come up with a new way to explain to children (ages 8+) how it is that
    when a person's genetic message is "copied," the result is another
    human being -- not a rabbit or an ear of corn.




    Based on a song written by Joel Herskowitz while he was in medical
    school, the "Double Talking Helix Blues" is a book and audio tape
    presentation on the structure and function of DNA. The book includes
    the text for Joel's song, which is illustrated with spectacular
    paintings by Judy Cuddihy to provide an important visual component to
    the overall "lesson" on DNA.


    Click here to listen to the Double Talking Helix Blues or right-click to download this MP3 file now.







    This is followed by a guide written by Ira Herskowitz to explain the
    scientific terms and concepts in the song; this section describes in
    clear terms what, for example, a chromosome, nucleus, and molecule
    are. Accompanying the book is a 12-minute audio tape with performances
    of the song by Joel and Ira.




    All in all, the "Double Talking Helix Blues" provides young readers
    with a wonderful introduction to concepts of cells and molecules,
    reproduction at the molecular level, and DNA and its structure.
    The target age group for this presentation is ages 8 and up, as well
    as teachers, scientists, and all those interested in molecular
    biology at its most basic level.

    Author
      Joel HerskowitzNew England Medical Center Hospitals, Boston
    Contributor
      Judy CuddihyCold Spring Harbor Laboratory
    Publication DateJanuary 1994/1994
    Bibliographic Information
    32 fully illustrated 4-color pages, plus a 12-minute audiocassette
    Set Info
    Topics

    Title   Drosophila Neurobiology: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/drosneurop.htm
    ISBN978-0-879699-05-5
    Price$154.00
    Series Information: 
    Cold Spring Harbor Laboratory’s long-running Neurobiology of Drosophila course has trained a generation of neuroscientists, many of whom have become leaders in the field. Drosophila Neurobiology: A Laboratory Manual offers the detailed protocols and background material developed by the course instructors to all researchers interested in using Drosophila as an experimental model for investigating the nervous system. The manual covers three approaches to the field: Studying Neural Development in Drosophila melanogaster, Recording and Imaging in the Drosophila Nervous System, and Studying Behavior in Drosophila. Techniques described include molecular, genetic, electrophysiological, imaging, behavioral and developmental methods. Written by leading experts from the community, Drosophila Neurobiology: A Laboratory Manual is an essential guide for researchers at all levels, from the beginning graduate student through the established primary investigator.
    Editor
      Bing ZhangUniversity of Oklahoma
    Publication Date2010/2010
    Bibliographic Information
    534 pp., illus. (70 color, 43 b/w), appendix, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Drosophila Neurobiology: A Laboratory Manual
    Invertebrate Neurobiology
    An Introduction to Nervous Systems
    An Introduction to Nervous Systems

    Title   Drosophila Neurobiology: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/drosneuro.htm
    ISBN978-0-879699-04-8
    Price$256.00
    Series Information: 
    Cold Spring Harbor Laboratory’s long-running Neurobiology of Drosophila course has trained a generation of neuroscientists, many of whom have become leaders in the field. Drosophila Neurobiology: A Laboratory Manual offers the detailed protocols and background material developed by the course instructors to all researchers interested in using Drosophila as an experimental model for investigating the nervous system. The manual covers three approaches to the field: Studying Neural Development in Drosophila melanogaster, Recording and Imaging in the Drosophila Nervous System, and Studying Behavior in Drosophila. Techniques described include molecular, genetic, electrophysiological, imaging, behavioral and developmental methods. Written by leading experts from the community, Drosophila Neurobiology: A Laboratory Manual is an essential guide for researchers at all levels, from the beginning graduate student through the established primary investigator.
    Editor
      Bing ZhangUniversity of Oklahoma
    Publication Date2010/2010
    Bibliographic Information
    534 pp., illus. (70 color, 43 b/w), appendix, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Drosophila Neurobiology: A Laboratory Manual
    Invertebrate Neurobiology
    An Introduction to Nervous Systems
    An Introduction to Nervous Systems

    Title   Drosophila Protocols
    Unique URL   http://www.cshlpress.com/link/drosprotp.htm
    ISBN978-087969827-0
    Price$81.00
    Series Information: 


    This exceptional laboratory manual describes thirty-seven procedures
    most likely to be used in the next decade for molecular, biochemical,
    and cellular studies on Drosophila. They were selected after
    extensive consultation with the research community and rigorously
    edited for clarity, uniformity, and conciseness.




    The outstanding features of this protocol collection are:


    • Scope: The methods included permit investigation
      of chromosomes, cell biology, molecular biology, genomes,
      biochemistry, and development.

    • Depth: Each protocol includes the basic
      information needed by novices, with sufficient detail to be valuable
      to experienced investigators.

    • Format: Each method is carefully introduced and
      illustrated with figures, tables, illustrations, and examples of the
      data obtainable.

    • Added value: The book’s appendices include key
      aspects of Drosophila biology, essential solutions, buffers, and
      recipes.





    An evolution of Michael Ashburner’s 1989 classic Drosophila:
    A Laboratory Manual,
    this book is an essential addition to the
    personal library of Drosophila investigators and an incomparable
    resource for other research groups with goals likely to require
    fly-based technical approaches.

    Author
      William SullivanUniversity of California, Santa Cruz
    Publication DateMarch 2000/2000
    Bibliographic Information
    728 pp., illus., appendices, index
    Set Info
    Topics

    Title   The Dynamic Genome: Barbara McClintock's Ideas in the Century of Genetics
    Unique URL   http://www.cshlpress.com/link/dyngenp.htm
    ISBN978-087969396-1
    Price$29
    Series Information: 


    Barbara McClintock was born in 1902, within a few years of the
    rediscovery of Mendel's laws. Her life, discoveries, and insights
    span the history of genetics in this century.




    In the 1920s, she became a dominant figure in the group that
    flourished at Cornell University under R.A. Emerson and made
    remarkable technical and conceptual advances in maize cytogenetics.
    These studies continued at the California Institute of Technology,
    in Freiburg, Germany, and at the University of Missouri. In 1942,
    she joined the staff of the Carnegie Institution of Washington at
    Cold Spring Harbor, New York, where she became a Distinguished
    Service Member.




    McClintock's unique ability to discern relationships between the
    behavior of chromosomes and the properties of the whole organism
    earned her early recognition. She was elected to the National Academy
    of Sciences in 1944 and to the presidency of the Genetics Society of
    America in 1945. Had she done no more, McClintock would have become
    a major figure in the history of genetics.




    But at Cold Spring Harbor, she began the studies of the consequence
    of dicentric chromosome formation and breakage that led her to the
    discovery of genetic elements capable of moving within the genome
    and controlling expression of other genes. Although McClintock was
    universally respected and admired, the first reaction to these
    findings was often uncomprehending or indifferent, even dismissive.
    In due course, however, the generality of mobile genetic elements
    and the concept of a dynamic genome were understood and widely
    accepted, culminating in the award to McClintock of an unshared
    Nobel Prize in 1983.




    As Barbara's 90th birthday approached, some of her many friends and
    colleagues were invited to write essays for the occasion. This book
    contains a kaleidoscope of contributions, many by those who discovered
    transposition in other organisms. Their essays give a remarkable
    account of the scientific legacy of one of the century's greatest
    geneticists.

    Editor
      Nina FedoroffCarnegie Institution of Washington
    Publication DateJANUARY 1992/1992
    Bibliographic Information
    422 pp., illus, indexes

    This book has been produced using print on demand technology.
    Set Info
    Topics

    Title   The Early Days of Yeast Genetics
    Unique URL   http://www.cshlpress.com/link/earlydayp.htm
    ISBN978-087969874-4
    Price$61.00
    Series Information: 

    Yeast genetics began with Winge's 1935 studies of S. cerevisiae in Copenhagen, and afterwards was pursued by Lindegren in the U.S. and Ephrussi in France. Genetic studies in S. pombe were pioneered by Leupold in the 1940s in Switzerland. Within four decades, not without controversies, both yeast species were recognized as essential models in eukaryotic molecular cell biology. In this remarkable volume, Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before 1975 brought yeast biology to its current maturity. These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. This is a book that all scientists interested in the development of modern genetics and molecular biology should have on their shelves.


    Editor
      Michael N. HallBiozentrum der Universität Basel
    Select
      Patrick LinderBiozentrum der Universität Basel
    Publication DateJANUARY 1993/1993
    Bibliographic Information
    477 pp., illus., color plate, indexes
    Set Info
    Topics
    Related Products The Early Days of Yeast Genetics
    Phage and the Origins of Molecular Biology, The Centennial Edition

    Title   Early Development of Xenopus laevis: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/earlyxenp.htm
    ISBN978-087969942-0
    Price$40.00
    Series Information: 


    Amphibian embryos are supremely valuable in studies of early vertebrate development because they are large, handle easily, and can be obtained at many interesting stages. And of all the amphibians available for study, the most valuable is Xenopus laevis, which is easy to keep and ovulates at any time of year in response to simple hormone injections.



    Xenopus embryos have been studied for years but this is a particularly exciting time for the field. Techniques have become available very recently that permit a previously impossible degree of manipulation of gene expression in intact embryos, as well as the ability to visualize the results of such manipulation. As a result, a sophisticated new understanding of Xenopus development has emerged, which ensures the species’ continued prominent position among the organisms favored for biological investigation.



    This manual contains a comprehensive collection of protocols for the study of early development in Xenopus embryos. It is written by several of the field’s most prominent investigators in the light of the experience they gained as instructors in an intensive laboratory course taught at Cold Spring Harbor Laboratory since 1991. As a result it contains pointers, hints, and other technical knowledge not readily available elsewhere.


    This volume is essential reading for all investigators interested in the developmental and cell biology of Xenopus and vertebrates generally. Many of the techniques described here are illustrated in an accompanying set of videotapes which are cross-referenced to the appropriate section of the manual.

    Author
      Hazel L. SiveWhitehead Institute for Biomedical Research
    Publication Date2000/2000
    Bibliographic Information
    338 pp., illus., color plate, appendices, index
    Set Info
    Topics
    Related Products Early Development of Xenopus laevis: A Laboratory Manual
    Early Development of Xenopus laevis: A Laboratory Manual
    Manipulating the Early Embryo of Xenopus laevis: A Video Guide
    Manipulating the Early Embryo of Xenopus laevis: A Video Guide

    Title   The Eighth Day of Creation: The Makers of the Revolution in Biology
    (Commemorative Edition)

    Unique URL   http://www.cshlpress.com/link/eighthp.htm
    ISBN978-087969478-4
    Price$56.00
    Series Information: 

    In this classic book, the distinguished science writer Horace Freeland Judson tells the story of the birth and early development of molecular biology in the US, the UK, and France. The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published.


    This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.


    Author
      Horace Freeland Judson
    Publication Date1996/1996
    Bibliographic Information
    720 pp., illus., index, appendix, notes
    Set Info
    Topics

    Title   Emerging Model Organisms: A Laboratory Manual, Volume 1
    Unique URL   http://www.cshlpress.com/link/emop.htm
    ISBN978-087969872-0
    Price$89
    Series Information: 
    Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo
    Publication Date2009/2009
    Bibliographic Information
    592 pp., illus., appendix, index
    Set Info
    Topics
    Related Products Emerging Model Organisms: A Laboratory Manual, Volume 1

    Title   Emerging Model Organisms: A Laboratory Manual, Volume 1
    Unique URL   http://www.cshlpress.com/link/emo.htm
    ISBN978-087969826-3
    Price$158
    Series Information: 
    Until recently, a small number of model organisms has been the focus of most research in molecular, cellular, and developmental biology. But in the last few years, due in part to increased interest in questions of evolution, technical advances in selectively altering gene expression patterns, and the reduced costs of genome sequencing, the range of organisms used for research is greatly expanding. Emerging Model Organisms, Volume 1, introduces the reader to this new generation of model organisms, providing a diverse catalog of potential species useful for extending research in new directions. In this volume leading experts provide chapters on 23 emerging model systems, ranging from bat and butterfly to cave fish and choanoflagellates; cricket and finch to quail, snail, and tomato. Subsequent releases of the Emerging Model Organisms series, already in preparation, will focus on additional species. Material is also available in CSH Protocols: www.cshprotocols.org/emo
    Publication Date2009/2009
    Bibliographic Information
    592 pp., illus., appendix, index
    Set Info
    Topics
    Related Products Emerging Model Organisms: A Laboratory Manual, Volume 1

    Title   Emerging Model Organisms: A Laboratory Manual, Volume 2
    Unique URL   http://www.cshlpress.com/link/emo2.htm
    ISBN978-0-879699-45-1
    Price$162.00
    Series Information: 
    This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

    Review of Volume 1:

    “The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly
    advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now,
    he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome,
    describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology
    Publication Date2010/2010
    Bibliographic Information
    624 pp., illus. (102 b/w), appendices, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Emerging Model Organisms: A Laboratory Manual, Volume 2
    Emerging Model Organisms: A Laboratory Manual, Volume 1
    Emerging Model Organisms: A Laboratory Manual, Volume 1

    Title   Emerging Model Organisms: A Laboratory Manual, Volume 2
    Unique URL   http://www.cshlpress.com/link/emo2p.htm
    ISBN978-0-879698-65-2
    Price$91.00
    Series Information: 
    This second volume of the groundbreaking Emerging Model Organisms series expands the collection of species presented in the first volume. Leading experts provide 18 new chapters on emerging model systems, ranging from honeybee, ant, and beetle to Ciona and amphioxus; squid and salamander to yam, Paramecium, and wallaby. Like the first volume, each chapter presents a new organism and provides a detailed explanation of why it is useful for laboratory research, along with information on husbandry, genetics and genomics, pointers toward further resources, and a set of basic laboratory protocols for working with that organism. Emerging Model Organisms serves as a practical guidebook for finding just the right organism to address specific research needs.

    Review of Volume 1:

    “The first volume of Emerging Model Organisms illustrates the bewildering variety of natural histories and rapidly
    advancing techniques that have been developed to work with a wide spectrum of organisms. If Darwin were around now,
    he would have been the first to happily make use of this manual—and would be impatiently awaiting the forthcoming tome,
    describing the emergence of honeybees, squids, ascidians, rabbits, ants...and many more.” —Nature Cell Biology
    Publication Date2010/2010
    Bibliographic Information
    624 pp., illus. (102 b/w), appendices, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Emerging Model Organisms: A Laboratory Manual, Volume 2
    Emerging Model Organisms: A Laboratory Manual, Volume 1
    Emerging Model Organisms: A Laboratory Manual, Volume 1

    Title   Endocytosis
    Unique URL   http://www.cshlpress.com/link/endocytosis.htm
    ISBN978-1-621820-24-6
    Price$135
    Series Information: 

    During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of “cellular ingestion” is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. Pathogens (e.g., HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and postendocytic trafficking and how they regulate cellular and organismal physiology. Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. They review the numerous machineries (e.g., Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered.


    This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also for neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process.


    Editor
      Sandra L. SchmidUniversity of Texas Southwestern Medical Center
    Publication Date2014/2014
    Bibliographic Information
    590 pp., illus., index
    Set Info
    Topics

    Title   The Endoplasmic Reticulum
    Unique URL   http://www.cshlpress.com/link/endoplasret.htm
    ISBN978-1-936113-82-8
    Price$135
    Series Information: 

    The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed.

    This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication. Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER.


    Editor
      Susan Ferro-NovickUniversity of California, San Diego
    Publication Date2013/2013
    Bibliographic Information
    336 pp., illus (61 4C, 9 B&W), index
    Set Info
    Topics

    Title   Enjoy Your Cells
    Unique URL   http://www.cshlpress.com/link/enjycell.htm
    ISBN978-087969584-2
    Price$9.95
    Series Information: 


    Beneath your skin there is an amazing hidden world of living cells. Millions and millions
    of cells work together, to make everything that is you. But did you know that you started
    life as just one tiny cell? And did you know that everything that lives on Planet Earth is
    also made of these amazing cells?

    Author
      Fran Balkwill
    Publication DateNovember 2001/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics
    Related Products Enjoy Your Cells

    Title   Enjoy Your Cells
    Unique URL   http://www.cshlpress.com/link/enjycellhc.htm
    ISBN978-087969612-2
    Price$14.95
    Series Information: 


    Beneath your skin there is an amazing hidden world of living cells. Millions and millions
    of cells work together, to make everything that is you. But did you know that you started
    life as just one tiny cell? And did you know that everything that lives on Planet Earth is
    also made of these amazing cells?

    Author
      Fran Balkwill
    Publication DateNovember 2001/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics
    Related Products Enjoy Your Cells
    Gene Machines
    Gene Machines
    Have a Nice DNA
    Have a Nice DNA
    Germ Zappers
    Germ Zappers

    Title   Enjoy Your Cells-Balkwill/Rolph 4-book set
    Unique URL   http://www.cshlpress.com/link/enjoy4.htm
    ISBN9781621820017
    Price$55
    Series Information: 
    A collection of all four titles in the Enjoy Your Cells series for one low price.

    Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA.

    It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time—and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development…here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations—no expert required!

    This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues.

    Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.

    Volumes:
    Enjoy Your Cells
    Germ Zappers
    Have a Nice DNA!
    Gene Machines

     
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages in each book.

    Enjoy Your Cells ISBN 978-087969612-2

    Germ Zappers ISBN 978-087969598-9

    Have a Nice DNA ISBN 978-087969610-8

    Gene Machines ISBN 978-087969611-5
    Set Info
    Topics

    Title   Enjoy Your Cells-Balkwill/Rolph 4-book set
    Unique URL   http://www.cshlpress.com/link/enjoy4p.htm
    ISBN9781621820024
    Price$35
    Series Information: 
    A collection of all four titles in the Enjoy Your Cells series for one low price.

    Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA.

    It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time—and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development…here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations—no expert required!

    This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues.

    Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.

    Volumes:
    Enjoy Your Cells
    Germ Zappers
    Have a Nice DNA!
    Gene Machines

     
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages in each book.

    Enjoy Your Cells ISBN 978-087969584-2

    Germ Zappers ISBN 978-087969598-9

    Have a Nice DNA ISBN 978-087969610-8

    Gene Machines ISBN 978-087969611-5
    Set Info
    Topics

    Title   Epigenetics
    Unique URL   http://www.cshlpress.com/link/sym69.htm
    ISBN978-087969729-7
    Price$310
    Series Information: 
    The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.
    Editor
      Bruce StillmanCold Spring Harbor Laboratory
    Publication Date2004/2004
    Bibliographic Information
    532 pp., illus., index
    Set Info
    Topics
    Related Products Epigenetics
    Epigenetics

    Title   Epigenetics
    Unique URL   http://www.cshlpress.com/link/sym69p.htm
    ISBN978-087969731-0
    Price$126
    Series Information: 
    The importance of epigenetic regulation of gene expression, particularly in higher organisms, is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into the underlying mechanisms. The resulting volume—with over 60 papers from experts across the field—covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.
    Editor
      Bruce StillmanCold Spring Harbor Laboratory
    Publication Date2004/2004
    Bibliographic Information
    532 pp., illus., index
    Set Info
    Topics
    Related Products Epigenetics
    Epigenetics

    Title   Epigenetics
    Unique URL   http://www.cshlpress.com/link/epigenp.htm
    ISBN978-087969875-1
    Price$91.00
    Series Information: 

    The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

    Editor
      C. David AllisThe Rockefeller University, New York
    Publication Date2007/2007
    Bibliographic Information
    502 pp., illus., appendices, index
    Set Info
    Topics
    Related Products Epigenetics, Second edition
    Epigenetics
    Epigenetics
    Epigenetics

    Title   Epigenetics, Second edition
    Unique URL   http://www.cshlpress.com/link/epigen2.htm
    ISBN978-1-936113-59-0
    Price$165
    Series Information: 

    An understanding of epigenetics is central to research in transcriptional regulation, development, and disease. The second edition of the best-selling Epigenetics textbook builds on the strong foundation of the first edition, expanding from 24 to 36 expertly written chapters. Revised chapters from the first edition cover the basic molecular mechanisms underpinning epigenetic regulation, discussing many cellular processes that rely on this kind of regulation, and survey the studies carried out in the whole spectrum of model organisms in which it has been most examined.


    New to the book is the inclusion of the expanding structural data on the machinery that modifies histones and DNA, giving weight and understanding to the molecular workings of chromatin and epigenetics. Also new is the inclusion of studies showing how chromatin remodeling machinery, and the higher order 3-D organization of the nucleus, are contributing to epigenetic regulation. A chapter is dedicated to the mounting evidence in mouse models of transgenerational epigenetic inheritance. Findings from studies of development, reprogramming, and disease highlight not only the importance of epigenetics but also the potential for epigenetic therapy, as illustrated in chapters covering the immune and neuronal systems, and cancer.


    This book is a major resource for those working in the field, as well as a suitable text for advanced undergraduate and graduate courses on gene regulation.

    Editor
      C. David AllisThe Rockefeller University
    Publication DateFebruary 2015/2014
    Bibliographic Information
    650 pp. (approx.), illus., index
    Set Info
    Topics

    Title   Essentials of Glycobiology, Second Edition
    Unique URL   http://www.cshlpress.com/link/glycobio2.htm
    ISBN978-087969770-9
    Price$162.00
    Series Information: 

    The sugar chains of cells—known collectively as glycans—play a variety of impressive, critical, and often surprising roles in biological systems. Glycobiology is the study of the roles of glycans in the growth and development, function, and survival of an organism. Glyco-related processes, described in vivid detail in the text, have become increasingly significant in many areas of basic research as well as biomedicine and biotechnology.


    This new edition of Essentials of Glycobiology covers the general principles and describes the structure and biosynthesis, diversity, and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of glycobiology. “Glycomics,” analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism and paves the way for a more thorough understanding of the functions of these ubiquitous molecules.


    The first edition of Essentials of Glycobiology represented also a notable experiment in publishing, as it became one of the first electronic textbooks. And, now, in recognition of its wide audience and the changing ways in which researchers and students learn and access information, the new edition of Essentials will be made available online simultaneously with the print edition. This novel experiment is the result of the collaborative efforts of the Cold Spring Harbor Laboratory Press, the National Center for Biotechnology Information, and the editors of the book. Written and edited by glycobiologists with experience in teaching and in research, this volume will be an invaluable resource, both for students and for established investigators in fields such as developmental biology, cell biology, neuroscience, immunology, and biochemistry who require a complete yet concise introduction to this burgeoning field.


    Advance praise for the Second Edition:

    “The basic principles of glycobiology are clearly articulated in this volume, and the roles of complex carbohydrates in disease are an important read for all biomedical scientists.”

    —Peter Agre, M.D., Nobel Laureate in Chemistry, 2003


    “Essentials of Glycobiology is a major resource for understanding these post-translational biochemical reactions that affect the function and fate of proteins produced by the genes that are profoundly changed by their added sugars.”

    —Baruch S. Blumberg, Nobel Laureate in Medicine, 1976


    “The second edition of Essentials of Glycobiology, superbly printed and illustrated, develops in simple and absolutely precise terms the complicated intricacies of glycobiology. I would have killed to get this encyclopedic treatise 40 years ago when I was working my way through this field.”

    —Edmond H. Fischer, Nobel Laureate in Medicine, 1992

     

    Editor
      Ajit VarkiUniversity of California, San Diego
    Publication Date2009/2009
    Bibliographic Information
    784 pp., illus. glossary, study guide, index
    Set Info
    Topics
    Related Products Essentials of Glycobiology

    Title   Evolution
    Unique URL   http://www.cshlpress.com/link/evolutn.htm
    ISBN978-087969684-9
    Price$113.00
    Series Information: 
    Evolution is a new book on evolutionary biology that integrates molecular biology, genomics, and human genetics with traditional studies of evolutionary processes.

    • Recommended as a primary textbook for undergraduate courses in evolution

    • Required reading for biologists seeking a clear, current, and comprehensive account of evolutionary theory and mechanisms

    • Written by experts in population genetics, bacterial genomics, paleontology, human genetics, and developmental biology

    • Integrates molecular and evolutionary biology in ways that reflect current directions in research



    Contents and Coverage

    This extensively illustrated, full-color book has four sections:

    Introduction (Part I) gives an account of how the ideas underpinning evolutionary theory developed and a history of experiments and ideas in the development of molecular biology.

    Origin and Diversification of Life (Part II) describes the history of life on earth from the origin of life to the evolution of humans, with emphasis on the major transitions in genetic organization and novel adaptations that have appeared. The diversity of life is emphasized. The chapters make extensive use of information from complete genome sequences and analysis of molecular mechanisms in development.

    Evolutionary Processes (Part III) describes how the diversity of life is generated: How variation arises and how selection acts are considered in detail. Many examples used to illustrate these processes are drawn from molecular sources.

    Human Evolution (Part IV) discusses human evolution and diversity. The benefits of molecular markers for our understanding of human evolution are highlighted and these findings integrated with paleontological evidence. Also discussed is the use of evolutionary methods to identify genetic differences that predispose people to specific diseases and affect their responses to treatment.

    Online-only Chapters

    Additional chapters, found on the Web only, deal with techniques and models used in studying evolutionary biology, emphasizing the contribution of molecular biology and genomics to phylogenetic reconstruction methods.
    Resources for Instructors

    The Evolution Web site (www.evolution-textbook.org) is an invaluable supplement to the textbook, a resource for teachers that will contain downloadable figures (for PowerPoint or overhead display) and chapter problems.

    Request exam copies and other information

    Visit the Evolution Web site now for more information about this new book. Request a detailed Table of Contents, Sample Chapters, Exam Copies, and Updates about Evolution.

    Author
      Nicholas H. BartonUniversity of Edinburgh
    Publication Date2007/2007
    Bibliographic Information
    833 pp., color illus., glossary, index
    Price subject to change
    Set Info
    Topics
    Related Products Evolution: The Molecular Landscape
    Evolution: The Molecular Landscape




    Title   Evolution: The Molecular Landscape
    Unique URL   http://www.cshlpress.com/link/evoML.htm
    ISBN978-087969870-6
    Price$310
    Series Information: 

    This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions.


    The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few.

    A complete summary of the meeting can be found here.


    Editor
      Bruce StillmanCold Spring Harbor Laboratory
    Publication Date2009/2009
    Bibliographic Information
    485 pp., illus. 121 color; 86 b/w, indexes
    Trim size: 7-3/4” x 10-3/4”
    Set Info
    Topics
    Related Products Evolution: The Molecular Landscape
    Evolution

    Title   Evolution: The Molecular Landscape
    Unique URL   http://www.cshlpress.com/link/evoMLp.htm
    ISBN978-087969871-3
    Price$126
    Series Information: 

    This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions.


    The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few.

    A complete summary of the meeting can be found here.


    Editor
      Bruce StillmanCold Spring Harbor Laboratory
    Publication Date2009/2009
    Bibliographic Information
    485 pp., illus. 121 color; 86 b/w, indexes
    Trim size: 7-3/4” x 10-3/4”
    Set Info
    Topics
    Related Products Evolution: The Molecular Landscape
    Evolution

    Title   Evolution: The Molecular Landscape
    Unique URL   not available
    ISBN978-087969870-6
    Price$310
    Series Information: 

    This volume is based on presentations by the world-renowned investigators who gathered at the 74th annual Cold Spring Harbor Symposium on Quantitative Biology to celebrate the 150th anniversary of the publication of Charles Darwin’s On the Origin of Species. It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change. The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions.


    The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. O. Wilson (Harvard University); Jack W. Szostak (Harvard Medical School), a 2009 Nobel Prize winner who studies the chemistry of life's origins; and Nobel Prize winner and former president of HHMI Thomas Cech (Colorado Institute for Molecular Biotechnology), to name just a few.

    A complete summary of the meeting can be found here.


    Editor
      Bruce StillmanCold Spring Harbor Laboratory
    Publication Date2009/2009
    Bibliographic Information
    485 pp., illus. 121 color; 86 b/w, indexes
    Trim size: 7-3/4” x 10-3/4”
    Set Info
    Topics

    Title   Experimental Design for Biologists, Second Edition
    Unique URL   http://www.cshlpress.com/link/exdsnbio2.htm
    ISBN978-1-621820-41-3
    Price$39
    Series Information: 

    The effective design and analysis of experiments in biology are critical to success, yet graduate students in biological and medical sciences typically receive very little formal training in these steps. With feedback from readers of the first edition, colleagues, and students taking the very popular experimental design courses taught by the author, this second edition of Experimental Design for Biologists retains the engaging writing style while organizing the book around the four elements of experimental design: the framework, the system, the experiment, and the model. The approach has been tested in the classroom, where the author has taught numerous graduate students, MD/PhD students, and postdoctoral fellows. The goal of every scientist is to discover something new and with the aid of Experimental Design for Biologists, this task is made a little easier.


    This handbook explains how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. This thoroughly updated edition of Experimental Design for Biologists is an essential source of theory and practical guidance for designing a research plan.


    Author
      David J. GlassNovartis Institutes for Biomedical Research, Cambridge, Massachusetts
    Publication Date2014/2014
    Bibliographic Information
    304 pp., illus. (34 B&W), index
    Set Info
    Topics

    Title   Experimental Heart: A Novel
    Unique URL   http://www.cshlpress.com/link/exheartp.htm
    ISBN978-087969876-8
    Price$15.00
    Series Information: 

    Andy O'Hara, a post-doctoral researcher in a London cancer research institute, agrees to help an attractive colleague, Gina, who is collaborating with a pharmaceutical company. She is working on a virus-based vaccine but has discovered the company is planning a clinical trial of the vaccine in Africa without preliminary animal tests. Andy gets a tip-off that Gina's corporate collaborator has a shady past, but also discovers a scientific reason why the vaccine may be doomed to failure. As this excerpt begins, Andy and his friend Christine have helped Gina set up an illicit mouse experiment in their own animal facility, a move that could end all their careers if discovered.

    Read an excerpt here. —

    Author
      Jennifer L. Rohn
    Publication Date2009/2009
    Bibliographic Information
    364 pp.
    Set Info
    Topics
    Related Products The Honest Look

    Title   Extracellular Matrix Biology
    Unique URL   http://www.cshlpress.com/link/extracellular.htm
    ISBN978-1-936113-38-5
    Price$135
    Series Information: 

    In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis.


    Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM.


    Editor
      Richard O. HynesMassachusetts Institute of Technology
    Publication Date2012/2012
    Bibliographic Information
    387 pp., illus. (62 4C and 5 B&W), index
    Set Info
    Topics

    Title   Father to Son: Truth, Reason, and Decency
    Unique URL   http://www.cshlpress.com/link/fathertoson.htm
    ISBN978-1-621820-35-2
    Price$29
    Series Information: 

    At the age of 24, James Watson had a scientific discovery to his credit—the structure of DNA—that would win a Nobel Prize and forever change our understanding of genes and inheritance. Now, after a lifetime of accomplishment in research, writing, education, and science advocacy, Watson has delved for the first time publicly into his own lineage to chronicle an archetypical American family from before the Civil War to Vietnam. With its portraits of many memorable characters, illustrated with previously unpublished photographs and period documents, Father To Son brilliantly illuminates the fundamental truth that who we become as individuals is determined by both our genetic and cultural heritage.


    Visit the Father to Son website here.

    Author
      James D. WatsonCold Spring Harbor Laboratory
    Publication Date2014/2014
    Bibliographic Information
    285 pages, illustrated, dust jacket
    Set Info
    Topics

    Title   Fly Pushing: The Theory and Practice of Drosophila Genetics, Second Edition
    Unique URL   http://www.cshlpress.com/link/fly2.htm
    ISBN978-087969711-2
    Price$61.00
    Series Information: 
    A second edition of the classic handbook has become a standard in the Drosophila field. This edition is expanded to include topics in which classical genetic strategies have been augmented with new molecular tools. Included are such new techniques as homologous recombination, RNAi, new mapping techniques, and new mosaic marking techniques.
    Author
      Ralph J. GreenspanThe Neurosciences Institute, San Diego
    Publication Date2004/2004
    Bibliographic Information
    191 pp., illus., appendices, index
    Set Info
    Topics
    Related Products An Introduction to Nervous Systems
    An Introduction to Nervous Systems
    Invertebrate Neurobiology

    Title   Francis Crick: Hunter of Life’s Secrets
    Unique URL   http://www.cshlpress.com/link/crick.htm
    ISBN978-087969798-3
    Price$46.00
    Series Information: 

    This engrossing biography by one of molecular biology’s foremost scholars reveals the remarkable evolution of Francis Crick’s scientific career and the shaping of his personality. From unpromising beginnings, he became a vital contributor to a remarkably creative period in science. Olby chronicles Crick’s life from his early studies in biophysics, to the discovery of the structure of DNA, to his later work in neuroscience and the nature of consciousness. This account is woven together with insights into his personal life gained through access to Crick’s papers, family, and friends. Robert Olby’s book is a richly detailed portrait of one of the great scientists of our time.

    About the author: Robert Olby, a prominent historian of science, is research professor in the Department of History and Philosophy of Science at the University of Pittsburgh and author of the highly regarded Origins of Mendelism (1966, 1985) and The Path to the Double Helix (1974, 1994). He has published and lectured widely on 19th and 20th century topics in biology, genetics, and molecular biology. Olby is a member of the History of Science Society and the International Academy of the History of Science.


    Author
      Robert Olby
    Publication Date2009/2009
    Bibliographic Information
    538 pp, illus., indexes
    Set Info
    Topics

    Title   Gastrulation: From Cells to Embryo
    Unique URL   http://www.cshlpress.com/link/gastrul.htm
    ISBN978-087969707-5
    Price$158
    Series Information: 
    During gastrulation, tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.
    Editor
      Claudio D. SternUniversity College London
    Publication Date2004/2004
    Bibliographic Information
    731 pp., illus., appendices, index
    Set Info
    Topics

    Title   Gene Function in Prokaryotes
    Unique URL   http://www.cshlpress.com/link/gfprok.htm
    ISBN978-087969176-9
    Price$37
    Series Information: 
    Publication Date1983/1983
    Bibliographic Information
    328 pp., illus., index
    Set Info
    Topics

    Title   Gene Machines
    Unique URL   http://www.cshlpress.com/link/genemachhc.htm
    ISBN978-087969616-0
    Price$14.95
    Series Information: 
    Author
      Fran Balkwill
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics

    Title   Gene Machines
    Unique URL   http://www.cshlpress.com/link/genemach.htm
    ISBN978-087969611-5
    Price$9.95
    Series Information: 
    Author
      Fran Balkwill
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics

    Title   Gene Therapy: Fact and Fiction in Biology's New Approaches to Disease
    Unique URL   http://www.cshlpress.com/link/genefact.htm
    ISBN978-087969446-3
    Price$16
    Series Information: 


    In 1982, a meeting of unusual influence was held at the Banbury
    Conference Center of Cold Spring Harbor Laboratory. After an early
    attempt at treating clinical disease with transferred genes had
    ignited public attention and scientific controversy, a group of
    distinguished biologists and physicians came together to assess
    practical progress towards gene therapy and what its future might be.
    The geneticist Ted Friedmann wrote a narrative account of the
    participants' contributions to the meeting, ending with a personal
    discussion of ethical issues raised by genetic technologies.




    His book, the first on gene therapy, was widely read but has long
    been unavailable. It has been reprinted with a new introduction by
    the author, in which he reviews the field's technical accomplishments
    and ethical dilemmas. Now that gene therapy has become part of the
    medical landscape, this volume is of interest as both a historical
    document and an assessment of the field's current challenges.

    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication DateJanuary 1994/1994
    Bibliographic Information
    124 pp.
    Set Info
    Topics

    Title   Chapter 1 - From Germs to Genes
    Unique URL   not available
    ISBN0-87969-446-7-1
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 2 - On the Road to Gene Therapy
    Unique URL   not available
    ISBN0-87969-446-7-2
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 3 - We Can't Start and We Can't Stop
    Unique URL   not available
    ISBN0-87969-446-7-3
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 4 - 3000 Genetic Diseases
    Unique URL   not available
    ISBN0-87969-446-7-4
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 5 - Treating Genetic Disease Without Treating Genes
    Unique URL   not available
    ISBN0-87969-446-7-5
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 6 - Gene Fixing — The Realities and the Potential
    Unique URL   not available
    ISBN0-87969-446-7-6
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Chapter 7 - Experiment or Treatment? A Personal View
    Unique URL   not available
    ISBN0-87969-446-7-7
    Price$15.00
    Electronic Document
    Series Information: 
    Author
      Theodore Friedmann, M.D.University of California, San Diego
    Publication Date/1994
    Bibliographic Information
    Set Info
    Topics

    Title   Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/genetrnp.htm
    ISBN978-087969765-5
    Price$167
    Series Information: 
    Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.
    Editor
      Theodore FriedmannUniversity of California, San Diego
    Publication Date2007/2007
    Bibliographic Information
    793 pp., illus., appendix, index
    Set Info
    Topics
    Related Products Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual
    The Development of Human Gene Therapy

    Title   Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/genetrn.htm
    ISBN978-087969764-8
    Price$263
    Series Information: 
    Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols cover a variety of methods, both well established and newly evolving. These include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response. The introductory matter to each chapter includes concise technical and theoretical discussions with considerations for selection of the appropriate system and strategies for delivery.
    Editor
      Theodore FriedmannUniversity of California, San Diego
    Publication Date2007/2007
    Bibliographic Information
    793 pp., illus., appendix, index
    Set Info
    Topics
    Related Products Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual
    The Development of Human Gene Therapy

    Title   Generation and Interpretation of Morphogen Gradients
    Unique URL   http://www.cshlpress.com/link/genintermorph.htm
    ISBN978-0-879698-81-2
    Price$135
    Series Information: 


    Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-β, and various growth factors, is essential during embryogenesis. The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.




    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores how morphogen gradients are generated and interpreted during development. The contributors examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells — whose fates are dictated by these morphogens.



    Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is an indispensable reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.


    Editor
      James BriscoeMRC National Institute for Medical Research
    Publication Date2010/2010
    Bibliographic Information
    308 pp., illus., index
    Set Info
    Topics

    Title   Genes & Signals
    Unique URL   http://www.cshlpress.com/link/genesig.htm
    ISBN978-087969633-7
    Price$39
    Series Information: 


    Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.

    Author
      Mark PtashneMemorial Sloan-Kettering Cancer Center
    Publication Date2002/2002
    Bibliographic Information
    192 pp., illus., index
    Set Info
    Topics
    Related Products Genes & Signals
    A Genetic Switch, Third Edition, Phage Lambda Revisited

    Title   Genes, Girls, and Gamow: After the Double Helix
    Unique URL   http://www.cshlpress.com/link/GGGWat.htm
    ISBN978-037541283-7
    Price$53
    Series Information: 

    FROM THE PUBLISHER (Alfred A. Knopf): Immediately following the revolutionary discovery of the structure of DNA by James D. Watson and Francis Crick in 1953, the world of molecular biology was caught up in a gold rush. The goal: to uncover the secrets of life that the newly elucidated molecule promised to reveal. Genes, Girls, and Gamow is James Watson’s report on the amazing aftermath of the DNA breakthrough, picking up where his now classic memoir, The Double Helix, leaves off.

    Here are the collaborations and collisions of giants, not only Watson and Crick themselves, but also legions of others, including Linus Pauling (the greatest chemist of the day), Richard Feynman (the bongo–playing cynosure of Caltech), and especially George Gamow, the bearlike, whiskey–wielding Russian physicist, who had turned his formidable intellect to the field of genetics; with Gamow—an irrepressible prankster to boot—Watson would found the legendary RNA Tie Club.

    But Watson—at twenty–five already the winner of genetic research’s greatest jackpot—is obsessed with another goal as well: to find love, and a wife equal to his unexpected fame. As he and an international cast of roguish young colleagues do important research they also compare notes and share complaints on the scarcity of eligible mates. And amid the feverish search for the role of the then still mysterious RNA molecule, Watson’s thoughts are seldom far from the supreme object of his desire, an enthralling Swarthmore coed who also happens to be the daughter of Harvard’s most eminent biologist.

    Part scientific apprenticeship, part sentimental education, Genes, Girls, and Gamow is a penetrating revelation of how great science is accomplished. It is also a charmingly candid account of one young man’s full range of ambitions.

    Author
      James D. WatsonCold Spring Harbor Laboratory
    Publication Date2001/2001
    Bibliographic Information
    336 pp., 43 illus., 22 letters
    NOTE: For distribution in the United States and Canada only.
    Set Info
    Topics

    Title   Genetic Map of Saccharomyces cerevisiae
    Unique URL   not available
    ISBN1808GM
    Price$15.00
    Electronic Document
    Series Information: 
    Appendix to The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, Metabolism and Gene Expression.
    Editor
      Robert K. MortimerDepartment of Biophysics and Medical Physics and Donner Laboratory, University of California, Berkeley
    Publication Date/1985
    Bibliographic Information
    Set Info
    Topics

    Title   A Genetic Switch, Third Edition, Phage Lambda Revisited
    Unique URL   http://www.cshlpress.com/link/genswitp.htm
    ISBN978-087969716-7
    Price$40.00
    Series Information: 
    The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
    Author
      Mark PtashneSloan-Kettering Memorial Cancer Center, New York
    Publication Date2004/2004
    Bibliographic Information
    154 pp., illus., appendices, index
    Set Info
    Topics
    Related Products Genes & Signals
    Genes & Signals

    Title   Genetic Variation: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/genevarp.htm
    ISBN978-087969780-8
    Price$165
    Series Information: 
    Genetic Variation: A Laboratory Manual is the first compendium of protocols specifically geared towards genetic variation studies, and includes thorough discussions on their applications for human and model organism studies. Intended for graduate students and professional scientists in clinical and research settings, it covers the complete spectrum of genetic variation—from SNPs and microsatellites to more complex DNA alterations, including copy number variation. Written and edited by leading scientists in the field, the early sections of the manual are devoted to study design and generating genotype data, the use of resources such as HapMap and dbSNP, as well as experimental, statistical, and bioinformatic approaches for analyzing the data. The final sections include descriptions of genetic variation in model organisms and discussions of recent insights into human genetic ancestry, forensics, and human variation.
    Editor
      Michael P. WeinerRainDance Technologies, Inc., Guilford, Connecticut
    Publication Date2007/2007
    Bibliographic Information
    472 pp., illus., appendix, index
    Set Info
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    Related Products Genetic Variation: A Laboratory Manual

    Title   The Genetics and Biology of Sexual Conflict
    Unique URL   http://www.cshlpress.com/link/genebiosexcon.htm
    ISBN978-1-621820-59-8
    Price$135
    Series Information: 

    The genetic interests of males and females often diverge; traits favored by one sex can be costly to the other. Over time, this “battle of the sexes,” or sexual conflict, has important evolutionary consequences (e.g., speciation).

    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the underlying biology of sexual conflict—from the molecular to the behavioral levels—and its role as an important driver of evolution. Contributors review multiple examples of sexual antagonism (e.g., parental care and mating rate), its genetic basis, the various and sometimes dramatic ways that it is manifested (e.g., infanticide and copulatory wounding), and its evolutionary impacts, especially on male–female coevolution and reproductive isolation. Topics such as hermaphroditism and homosexuality are also covered.


    This volume includes discussion of the evolutionary origins of sexual conflict and its relationship to other evolutionary forces (e.g., sexual selection). It will thus be fascinating reading for all geneticists and biologists who are interested in the evolution of sexual reproduction.


    Editor
      William RiceUniversity of California, Santa Barbara
    Publication Date2014/2014
    Bibliographic Information
    432 pp., illus. (26 4C, 18 B&W), index
    Set Info
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    Title   Genetics of Complex Human Diseases: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/gchd.htm
    ISBN978-087969882-9
    Price$162.00
    Series Information: 
    Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.
    Editor
      Ammar Al-ChalabiMRC Centre for Neurodegeneration Research, King’s College London
    Publication Date2009/2009
    Bibliographic Information
    220 pp., illus., index
    Set Info
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    Related Products Genetics of Complex Human Diseases: A Laboratory Manual

    Title   Genetics of Complex Human Diseases: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/gchdp.htm
    ISBN978-087969883-6
    Price$97.00
    Series Information: 
    Many human diseases—including Alzheimer’s disease, schizophrenia, cancer, and cardiovascular disease—show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book’s chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.
    Editor
      Ammar Al-ChalabiMRC Centre for Neurodegeneration Research, King’s College London
    Publication Date2009/2009
    Bibliographic Information
    220 pp., illus., index
    Set Info
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    Title   Genome Research Special Issue on Human Genome Variation
    Unique URL   http://www.cshlpress.com/link/GRHapMap.htm
    ISBN1088-9051 V15-N11
    Price$25
    Series Information: 
    The Genome Research November issue is a special issue devoted to a subject
    of great current interest, Human Genome Variation. The human genome consists
    of 3 billion base pairs of DNA, the sequence of which is 99.9% identical
    between any two unrelated people. The sites in the remaining 0.1%, where
    the DNA sequence commonly varies among people, are important for understanding
    susceptibility to complex diseases such as diabetes, cancer, stroke, heart
    disease, and psychiatric disorders.  This special issue is published
    concordant with Nature’s publication of The International HapMap Consortium’s
    haplotype map of the human genome, which is a public resource describing
    common genetic variation in the human genome expected to guide
    the design of studies aimed at finding variants contributing to human disease.


    This issue includes reports on diverse topics relating to population
    structure, demography, evolution, and whole genome association testing,
    including large–scale recombination patterns and linkage disequilibrium
    among populations, ascertainment bias in human genome–wide studies, novel
    methodologies to identify single nucleotide polymorphisms (SNPs)
    associated with cis–acting regulatory variants, choosing tagging SNPs, using SNPs to
    identify regions of positive selection in human populations, the role of
    segmental duplications in genomic disorders and specific examples of how
    these studies yield biologically relevant results in the form of
    identified susceptibility loci for important human diseases.  This special issue will
    also include a perspective on the determinants of  success of whole genome
    association testing, A User’s Guide to the HapMap Project website, and a
    poster that has been designed to be an educational resource demonstrating
    the data used to describe the patterns of human variation.

    Editor
      Hillary SussmanCold Spring Harbor Laboratory Press
    Publication DateNovember 2005/2005
    Bibliographic Information
    ISSN: 1088-9051; Volume 15, Genome Research Special Issue on Human Genome Variation
    Set Info
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    Related Products Genome Research 25% Discount Special Offer

    Title   Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes
    Unique URL   http://www.cshlpress.com/link/genscip.htm
    ISBN978-1-621821-09-0
    Price$39
    Series Information: 
    Genome Science is a textbook and laboratory manual for advanced secondary and post-secondary education. It combines approachable narrative with extensively tested lab exercises that illustrate key concepts of genome biology in humans, invertebrates, and plants. Nineteen labs, organized into four chapters, engage students with both bioinformatics exercises and in vitro experiments. Each chapter also includes an extensive introduction that provides an historical and conceptual framework. This modular structure offers many options for enhancing existing courses, starting new courses, or supporting student research projects. The book is complete with advice for instructors, laboratory planning guidelines, recipes for solutions, and answers to student questions.
    Select
      David Micklos
    Publication Date2014/2014
    Bibliographic Information
    704 pp., illus (3 4C, 606 B&W), index
    Set Info
    Topics
    Related Products DNA Science: A First Course, Second Edition

    Title   Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes
    Unique URL   http://www.cshlpress.com/link/gensci.htm
    ISBN978-0-879698-59-1
    Price$55
    Series Information: 
    Genome Science is a textbook and laboratory manual for advanced secondary and post-secondary education. It combines approachable narrative with extensively tested lab exercises that illustrate key concepts of genome biology in humans, invertebrates, and plants. Nineteen labs, organized into four chapters, engage students with both bioinformatics exercises and in vitro experiments. Each chapter also includes an extensive introduction that provides an historical and conceptual framework. This modular structure offers many options for enhancing existing courses, starting new courses, or supporting student research projects. The book is complete with advice for instructors, laboratory planning guidelines, recipes for solutions, and answers to student questions.
    Author
      David MicklosCold Spring Harbor Laboratory
    Publication Date2013/2013
    Bibliographic Information
    704 pp., illus (3 4C, 606 B&W), index
    Set Info
    Topics
    Related Products DNA Science: A First Course, Second Edition

    Title   Genomes
    Unique URL   http://www.cshlpress.com/link/genomes.htm
    ISBN978-087969806-5
    Price$139
    Series Information: 

    Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Research that capture the status of genomic research in a selection of model species—from microbes to human.

    Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, the future of crop plant genomics, how livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for “humanness” through human and chimp genome comparison. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given.

    This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.

    Editor
      Hillary E. SussmanCold Spring Harbor Laboratory
    Publication Date2006/2006
    Bibliographic Information
    475 pp., illus., index
    Set Info
    Topics
    Related Products Genomes
    The Dog and Its Genome

    Title   Genomes
    Unique URL   http://www.cshlpress.com/link/genomesp.htm
    ISBN978-087969807-2
    Price$59
    Series Information: 

    Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary issue of the journal Genome Research that capture the status of genomic research in a selection of model species—from microbes to human.

    Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research. Topics addressed include gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, the future of crop plant genomics, how livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for “humanness” through human and chimp genome comparison. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given.

    This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.

    Editor
      Hillary E. SussmanCold Spring Harbor Laboratory
    Publication Date2006/2006
    Bibliographic Information
    475 pp., illus., index
    Set Info
    Topics
    Related Products Genomes
    The Dog and Its Genome

    Title   George Beadle, An Uncommon Farmer: The Emergence of Genetics in the 20th Century
    Unique URL   http://www.cshlpress.com/link/uncmfarm.htm
    ISBN978-0879696-88-7
    Price$38
    Series Information: 
    George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize–winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.
    Author
      Paul BergStanford University School of Medicine
    Publication Date2003/2003
    Bibliographic Information
    383 pp., illus., index
    Set Info
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    Title   George Beadle, An Uncommon Farmer: The Emergence of Genetics in the 20th Century
    Unique URL   http://www.cshlpress.com/link/beadlep.htm
    ISBN978-087969763-1
    Price$21
    Series Information: 
    George Beadle was a towering scientific figure whose work from the 1930s to 1960 marked the transition from classical genetics to the molecular era. Among other distinctions, he made the pivotal, Nobel Prize–winning discovery with Edward Tatum that the role of genes is to specify proteins. From 1946 to 1960 he led the Caltech Biology Division, rebuilding it to a powerhouse in molecular biology, and afterwards became a successful President of the University of Chicago. This is the first biography of a giant of genetics, written by two of the field's most distinguished contributors, Paul Berg and Maxine Singer.
    Author
      Paul BergStanford University School of Medicine
    Publication Date2005/2005
    Bibliographic Information
    383 pp., illus., index
    Set Info
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    Related Products George Beadle, An Uncommon Farmer: The Emergence of Genetics in the 20th Century

    Title   Germ Cells
    Unique URL   http://www.cshlpress.com/link/germcells.htm
    ISBN978-1-936113-51-4
    Price$135
    Series Information: 

    In sexually reproducing organisms, germ cells give rise to gametes and serve as the link between generations. A key event during germ cell development is the decision to leave mitosis and enter meiosis, leading to the formation of mature eggs and sperm. Germ cell development involves unique gene expression programs and the establishment of epigenetic marks that ensure success during fertilization and embryo development.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the biology of germ cells in metazoans. The contributors describe the undifferentiated state of germline stem cells, the triggers for meiotic entry, and the transcriptional and post transcriptional controls during spermatogenesis and oogenesis that lead to the formation of mature gametes. The expression of sex linked genes and the establishment of genomic imprinting in the germline are also covered.


    This volume, which includes discussions of gamete recognition proteins, egg activation, and genetic reprogramming following nuclear transfer, is an indispensable reference for cell, molecular, and developmental biologists and anyone wishing to understand the implications of germ cell biology for reproductive technologies.


    Editor
      Paolo Sassone-CorsiUniversity of California, Irvine
    Publication Date2011/2011
    Bibliographic Information
    222 pp., illus. (26 4C and 12 B&W images), index
    Set Info
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    Title   Germ Zappers
    Unique URL   http://www.cshlpress.com/link/germzap.htm
    ISBN978-087969598-9
    Price$9.95
    Series Information: 


    Planet Earth can be a dangerous place for all living creatures, including you. You can
    usually escape from erupting volcanoes and floods. You can protect your body from the
    blazing Sun and freezing snow. But wherever you live and whatever the weather, you
    cannot escape GERMS!

    Author
      Fran Balkwill
    Publication DateNovember 2001/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics

    Title   Germ Zappers
    Unique URL   http://www.cshlpress.com/link/germzaphc.htm
    ISBN978-087969613-9
    Price$14.95
    Series Information: 


    Planet Earth can be a dangerous place for all living creatures, including you. You can
    usually escape from erupting volcanoes and floods. You can protect your body from the
    blazing Sun and freezing snow. But wherever you live and whatever the weather, you
    cannot escape GERMS!

    Author
      Fran Balkwill
    Publication DateNovember 2001/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics

    Title   Glia
    Unique URL   http://www.cshlpress.com/link/glia.htm
    ISBN978-1-621820-27-7
    Price$135
    Series Information: 

    Glia are cells that serve to nourish and support the neuronal cells that relay electrical signals through the nervous system. They also play critical roles in development and synapse formation, helping to establish neural circuits. This book examines our understanding of the basic biology of glia and their roles in diseases such as Alzheimer’s and cancer. What emerges from this work is new insight into the importance of glial cells, especially an appreciation that the development, function, and malfunction of our brains can only be understood as a signaling interplay between neurons and glial cells.


    Editor
      Ben A. BarresStanford University School of Medicine
    Publication DateDecember 2014/2014
    Bibliographic Information
    350 pp. (approx.), illus. (4C & B&W), index
    Set Info
    Topics

    Title   The Golgi
    Unique URL   http://www.cshlpress.com/link/golgi.htm
    ISBN978-0-87969-873-7
    Price$135
    Series Information: 

    Identified more than 100 years ago by Camillo Golgi, the Golgi is a series of flattened cisternae that acts as a critical sorting and processing station for intracellular traffic. It receives cargo in vesicles exported from the endoplasmic reticulum and then dispatches this to the plasma membrane for secretion or directs it to other organelles, such as endosomes. The Golgi also plays an important role in carbohydrate metabolism: It is the major site for attachment of sugar moieties to proteins.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions that review the current models for Golgi traffic and detail the functions of the cargo carrying machinery, such as the COPI and COPII vesicles, the glycosidases and glycosyltransferases that determine the oligosaccharide composition of the cargo, the various sorting signals, GTPases, and adaptor proteins involved, and the tethers and SNAREs that mediate vesicle fusion and deliver the cargo to the next compartment on the pathway. The contributors also examine recent insights into Golgi architecture and positioning, and the way the Golgi fragments and regenerates during cell division.


    This volume, which includes discussions of Golgi bypass mechanisms, the evolution and diversity of the Golgi, and the involvement of Golgi in development and human inherited diseases, serves as a comprehensive reference for all cell biologists interested in this intriguing organelle.


    Editor
      Graham WarrenUniversity of Vienna
    Publication Date2011/2011
    Bibliographic Information
    322 pp., illus. (56 4C and 12 B&W images), index
    Set Info
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    Title   Grounds for Knowledge
    A Guide to Cold Spring Harbor Laboratory’s Landscapes and Buildings
    Introducing the Bungtown Botanical Garden

    Unique URL   http://www.cshlpress.com/link/grounds.htm
    ISBN978-087969799-0
    Price$30.00
    Series Information: 

    Grounds for Knowledge is an engaging and knowledgeable guide to CSH Laboratory’s buildings both historic and new, and to the 150 species of trees that surround them. The superb color photography and detailed maps invite exploration of the newly designated Bungtown Botanical Garden. Buildings and landscapes of nearby Lab campuses in Woodbury, Lloyd Harbor, and Cold Spring Harbor are covered as well.

    About the author: Elizabeth Lewis Watson, a native of Providence, Rhode Island, graduated from Radcliffe College and has earned two master’s degrees – in Historic Preservation, from the Columbia University School of Architecture and Planning (1983); and in Library and Information Science, from the Palmer School of Long Island University (1997). She also holds honorary doctorates from the College of Charleston and Illinois Wesleyan University, where she has lectured on the preservation of historic landscapes.

    Author of Houses for Science (a centennial history of Cold Spring Harbor Laboratory, 1991), she also drafted the nomination papers that led to placement of the Laboratory’s main campus (along Bungtown Road) on the National Register of Historic Places, 1994. In addition, she authored A Limner’s View (a sailor’s view of world architecture, with “limner” Faith H. McCurdy, 1993) and contributed to The Mansions of Long Island, 1860-1940 (1997).

    Occupying various homes at “Bungtown” for nearly four decades, together with her husband James Dewey Watson and two now grown sons, Liz has always taken a delight in the grounds of the Laboratory – a pleasure heightened only recently by a course of study on the campus of the State University of New York at Farmingdale, in their program on Ornamental Horticulture. Long a trustee, plus a past president, of the Planting Fields Foundation of the Planting Fields Arboretum State Historic Park in nearby Oyster Bay, Long Island, she was instrumental in the Laboratory’s joining the American Association of Botanic Gardens and Arboreta (now the American Public Gardens Association) as the Bungtown Botanical Garden in 2006.

    A devoted trustee of the Society for the Preservation of Long Island Antiquities (SPLIA), Liz Watson has also served on the boards of the Cold Spring Harbor Whaling Museum and the Heckscher Museum of Art and as a member of the Huntington Historic Preservation Commission. She was appointed in 2001 to the New York State Board for Historic Preservation and currently serves also on the boards of the New York Landmarks Preservation Foundation and the Archives of American Art.

    Besides having become a manic “leaf peeper” (and aspiring to “bird watcher”) in her free time, Liz is an avid photographer, enthusiastic traveler, and happy hostess to those from near and far.


    Author
      Elizabeth L. Watson
    Publication Date2008/2008
    Bibliographic Information
    208 pp., illus., maps, appendices, bibliography, index
    Set Info
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    Related Products Houses for Science: A Pictorial History of Cold Spring Harbor Laboratory

    Title   Guide to the Human Genome
    Unique URL   http://www.cshlpress.com/link/guidehumgenp.htm
    ISBN978-0-879699-44-4
    Price$79
    Series Information: 
    Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure—from the molecular and cellular levels to developmental and physiological processes. In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest.
    Author
      Stewart Scherer
    Publication Date2011/2011
    Bibliographic Information
    1,008 pp., illus. (212 b/w), appendix, index
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    Title   Have a Nice DNA
    Unique URL   http://www.cshlpress.com/link/nicedna.htm
    ISBN978-087969610-8
    Price$9.95
    Series Information: 
    Author
      Fran Balkwill
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
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    Title   Have a Nice DNA
    Unique URL   http://www.cshlpress.com/link/havedna.htm
    ISBN978-087969614-6
    Price$14.95
    Series Information: 
    Author
      Fran Balkwill
    Publication Date2002/2002
    Bibliographic Information
    32 fully illustrated 4-color pages
    Set Info
    Topics

    Title   Hemoglobin and Its Diseases
    Unique URL   http://www.cshlpress.com/link/hemoglobin.htm
    ISBN978-1-936113-45-3
    Price$135
    Series Information: 

    Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered by genetic mutations. More than 1000 hemoglobin disorders are known; hemoglobinopathies (e.g., sickle cell disease) and thalassemias are some of the most common human genetic diseases worldwide.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of hemoglobin and its diseases. Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations. The pathophysiological consequences of hemoglobin disorders (e.g., ineffective erythropoiesis and aberrant iron homeostasis), their clinical manifestations, and epidemiological trends are also described.


    This book includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. It is an indispensable reference for biochemists, geneticists, cell and developmental biologists, physiologists, and all who are interested in reducing the medical burden of these common genetic diseases.


    Editor
      David WeatherallWeatherall Institute of Molecular Medicine
    Publication Date2013/2013
    Bibliographic Information
    445 pp., illus. (66 4C, 19 B&W). index
    Set Info
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    Title   A History of Genetics
    Unique URL   http://www.cshlpress.com/link/histgene.htm
    ISBN978-087969607-8
    Price$21.00
    Series Information: 


    In the small “Fly Room” at Columbia University, T.H. Morgan
    and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller,
    carried out the work that laid the foundations of modern, chromosomal
    genetics. The excitement of those times, when the whole field of
    genetics was being created, is captured in this book, written in 1965
    by one of those present at the beginning. His account is one of the
    few authoritative, analytic works on the early history of genetics.
    This attractive reprint is accompanied by a

    website
    offering full-text versions of the key
    papers discussed in the book, including the world’s first genetic map.

    Author
      A.H. SturtevantCalifornia Institute of Technology
    Contributor
      Edward B. Lewis
    Publication DateJanuary 2001/2001
    Bibliographic Information
    174 pp., illus., appendices, bibliography, index

    This book has been produced using print on demand technology.
    Set Info
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    Title   HIV: From Biology to Prevention and Treatment
    Unique URL   http://www.cshlpress.com/link/HIVbioprevtreat.htm
    ISBN978-1-936113-40-8
    Price$135
    Series Information: 

    The worldwide AIDS epidemic makes research on HIV, the disease processes it induces, and potential HIV therapies among the most critical in biomedical science. Furthermore, the basic biology of HIV infections provides a model for a more general understanding of retroviruses and their hosts.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of HIV research, covering everything from the pathogenesis of HIV infection to prevention. Contributors explore the origins and evolution of HIV, the HIV replication cycle, host–virus interactions, host immune responses, and HIV transmission. Vaccines, cell and gene therapies, antiretroviral drugs, microbicides, and behavioral strategies for the treatment and prevention of HIV infections are also explored.


    This volume, which includes discussions of social and economic factors that affect HIV transmission and treatment, is an essential reference for virologists, cell and molecular biologists, and immunologists, as well as epidemiologists, physicians, and other public health professionals.


    Editor
      Frederic D. BushmanUniversity of Pennsylvania School of Medicine
    Publication DateDecember 2011/2011
    Bibliographic Information
    572 pp., illus. (95 4C and 4 B&W), index
    Set Info
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    Title   The Honest Look
    Unique URL   http://www.cshlpress.com/link/honestlook.htm
    ISBN978-1-936113-11-8
    Price$15.00
    Series Information: 

    In becoming a scientist, Claire Cyrus hopes to escape the fate of her dead father, a brilliant but critically unsuccessful poet whose poverty and bitterness derailed her own strong talent for verse. Soon after moving from England to take up her first job in a start-up biotech company in the Netherlands, she finds herself an outcast in her strange new environment, shunned by her jealous colleagues and moving only on the fringes of the expatriate community. But when she makes an accidental discovery in the lab, her life will never be the same again.

    The Honest Look is a tale of passion, betrayal and a devastating secret that threatens to bring down careers, a company and a widely accepted scientific theory. Unfolding in the modern corporate laboratory, where the idealism of advancing knowledge and the uncompromising reality of profit margins exist in uneasy truce, this is a story of how people with various stakes in a common endeavour react when its integrity is called into question, and how these reactions can be shaped—and warped—by denial, greed, hatred and love.


     


    Author
      Jennifer L. Rohn
    Publication Date2011/2011
    Bibliographic Information
    300 pp.
    Set Info
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    Related Products Experimental Heart: A Novel

    Title   Human Fungal Pathogens
    Unique URL   http://www.cshlpress.com/link/humfungalpath.htm
    ISBN978-1-621820-75-8
    Price$135
    Series Information: 

    Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete’s foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans—their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored.


    This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens.


    Editor
      Arturo CasadevallAlbert Einstein College of Medicine of Yeshiva University
    Publication DateDecember 2014/2014
    Bibliographic Information
    580 pp. (approx.), illus. (45 4C, 13 B&W), index
    Set Info
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    Title   Human Variation: A Genetic Perspective on Diversity, Race, and Medicine
    Unique URL   http://www.cshlpress.com/link/humanvarp.htm
    ISBN978-1-936113-25-5
    Price$59
    Series Information: 

    Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance, skin color, food tolerance, and susceptibility to different diseases. Large-scale DNA sequencing is now allowing us to map the patterns of human genetic variation more accurately than ever before, trace our ancestries, and develop personalized therapies for particular diseases. It is also reinforcing the idea that human populations are far from homogeneous, are highly intermixed, and do not fall into distinct races or castes that can be defined genetically.


    This book provides a state-of-the-art view of human genetic variation and what we can infer from it, surveying the genetic diversity seen in Africa, Europe, the Americas, and India. The contributors discuss what this can tell us about human history and how it can be used to improve human health. They also caution against assumptions that differences between individuals always stem from our DNA, stressing the importance of nongenetic forces and pointing out the limits of our knowledge. The book is thus essential reading for all human geneticists and anyone interested in how we differ and what this means.


    Editor
      Aravinda ChakravartiJohns Hopkins University School of Medicine, Institute of Genetic Medicine
    Publication Date2014/2014
    Bibliographic Information
    131 pp., illus. (21 4C, 5B&W), index
    Set Info
    Topics

    Title   Human Variation: A Genetic Perspective on Diversity, Race, and Medicine
    Unique URL   http://www.cshlpress.com/link/humanvar.htm
    ISBN978-1-621820-90-1
    Price$75
    Series Information: 

    Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance, skin color, food tolerance, and susceptibility to different diseases. Large-scale DNA sequencing is now allowing us to map the patterns of human genetic variation more accurately than ever before, trace our ancestries, and develop personalized therapies for particular diseases. It is also reinforcing the idea that human populations are far from homogeneous, are highly intermixed, and do not fall into distinct races or castes that can be defined genetically.


    This book provides a state-of-the-art view of human genetic variation and what we can infer from it, surveying the genetic diversity seen in Africa, Europe, the Americas, and India. The contributors discuss what this can tell us about human history and how it can be used to improve human health. They also caution against assumptions that differences between individuals always stem from our DNA, stressing the importance of nongenetic forces and pointing out the limits of our knowledge. The book is thus essential reading for all human geneticists and anyone interested in how we differ and what this means.


    Editor
      Aravinda ChakravartiJohns Hopkins University School of Medicine, Institute of Genetic Medicine
    Publication Date2014/2014
    Bibliographic Information
    131 pp., illus. (21 4C, 5B&W), index
    Set Info
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    Title   I Wish I'd Made You Angry Earlier: Essays on Science, Scientists, and Humanity
    Unique URL   http://www.cshlpress.com/link/iwishpap.htm
    ISBN978-087969674-0
    Price$16
    Series Information: 

    Science is no quiet life. Imagination, creativity, ambition, and conflict are as vital and abundant in science as in artistic endeavors. In this collection of essays, the Nobel Prize–winning protein chemist Max Perutz writes about the pursuit of scientific knowledge, which he sees as an enterprise providing not just new facts but cause for reflection and revelation, as in a poem or painting.

    Max Perutz's essays explore a remarkable range of scientific topics with the lucidity and precision Perutz brought to his own pioneering work in protein crystallography. He has been hailed as an author who "makes difficult subjects intelligible and writes with the warmth, humanity, and broad culture which has always characterized the great men of science." Of his previous collection of essays, a reviewer said "They turn the world of science and medicine into a marvelous land of adventure which I was thrilled to explore in the company of this wise and human [writer]." Readers of this volume can journey to the same land, with the same delight.


    Max Perutz (1914–2002) was a brilliant scientist, a visionary of molecular biology, and a writer of elegant essays infused with humanity and wisdom. This expanded paperback edition of his very successful book I Wish I'd Made You Angry Earlier contains nine additional essays, and a warmly evocative portrait of Max by his friend and professional colleague Sir John Meurig Thomas.




    The original hardcover edition of this book was co-published
    with Oxford University Press. A paperback edition is also available from Oxford University Press. The expanded paperback edition is only available from Cold Spring Harbor Laboratory Press.




    Translation Information


    Shanghai Scientific & Technical Publishers—Chinese Translation Rights (simple character)

    Baldini & Castoldi—Italian Translation Rights

    Editions Odile Jacob—French Translation Rights

    Verlag Brueder Hollinek—German Translation Rights

    Author
      Max F. Perutzformerly Chairman and Member of the MRC Laboratory of Molecular Biology, Cambridge, England
    Publication Date2003/2003
    Bibliographic Information
    460 pp., index
    Set Info
    Topics
    Related Products I Wish I'd Made You Angry Earlier: Essays on Science, Scientists, and Humanity
    Max Perutz and the Secret of Life

    Title   Illuminating Life: Selected Papers from Cold Spring Harbor, Volume 1 (1903–1969)
    Unique URL   http://www.cshlpress.com/link/illumlif.htm
    ISBN978-087969566-8
    Price$26
    Series Information: 


    The Laboratory that bears the Cold Spring Harbor name is famous for
    its research, its role in science education, and the science that won
    three recent Nobel prizes. This book, an intellectual history of
    Cold Spring Harbor Laboratory, can be enjoyed by anyone interested in
    the development of contemporary science, regardless of technical
    background. It is assembled on the foundation of twenty research
    papers published between 1903 and 1969. Now hard to track down, they
    are reproduced in facsimile and accompanied by a series of essays by
    Jan Witkowski describing the investigations that were done, who did
    them, and why they were important. This handsome volume will appeal
    to students, established scientists, and others intrigued not only by
    the history of research at Cold Spring Harbor but also by an
    extraordinary period in the flowering of American science.

    Author
      Jan WitkowskiCold Spring Harbor Laboratory
    Publication DateNovember 1999/2000
    Bibliographic Information
    383 pp., illus., index
    Set Info
    Topics
    Related Products Life Illuminated: Selected Papers from Cold Spring Harbor
    Volume 2, 1972–1994


    Title   Imaging in Developmental Biology: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imagingdevbiop.htm
    ISBN978-0-879699-40-6
    Price$169.00
    Series Information: 
    New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization methods. The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. Methods range from the basics of labeling cells to cutting-edge protocols for high-speed imaging, optical projection tomography, and digital scanned laser light-sheet fluorescence. Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques.
    Editor
      James SharpeEMBL-CRG Systems Biology Unit, Barcelona, Spain
    Publication Date2011/2011
    Bibliographic Information
    883 pp., illus., index
    Set Info
    Topics
    Related Products Imaging in Developmental Biology: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual

    Title   Imaging in Developmental Biology: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imagingdevbio.htm
    ISBN978-0-879699-39-0
    Price$246.00
    Series Information: 
    New imaging technologies have revolutionized the study of developmental biology. Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. Imaging in Developmental Biology: A Laboratory Manual, a new volume in Cold Spring Harbor Laboratory Press’ Imaging series, presents a comprehensive set of essential visualization methods. The manual features primers on live imaging of a variety of standard model organisms including C. elegans, Drosophila, zebrafish, Xenopus, avian species, and mouse. Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. Methods range from the basics of labeling cells to cutting-edge protocols for high-speed imaging, optical projection tomography, and digital scanned laser light-sheet fluorescence. Imaging has become a required methodology for developmental biologists, and Imaging in Developmental Biology: A Laboratory Manual provides the detailed explanations and instructions for mastering these necessary techniques.
    Editor
      James SharpeEMBL-CRG Systems Biology Unit, Barcelona, Spain
    Publication Date2011/2011
    Bibliographic Information
    883 pp., illus., index
    Set Info
    Topics
    Related Products Imaging in Developmental Biology: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual

    Title   Imaging in Neuroscience: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imagingneuro.htm
    ISBN978-0-879699-37-6
    Price$287.00
    Series Information: 
    As imaging technologies have revolutionized research in many areas of biology and medicine, neuroscientists have often pioneered the use of new visualization techniques. Imaging in Neuroscience: A Laboratory Manual provides the definitive collection of methods in use in this groundbreaking field. With more than 90 chapters, the manual offers a depth of coverage unavailable from any other source. Sections focus on imaging at the molecular level, axons and nerve terminals, spines and dendrites, neurons and circuits in vitro, neurons and circuits in vivo, glia, brain dynamics and behavior, and brain pathology. Protocols range from basic techniques to recent breakthroughs. Imaging in Neuroscience: A Laboratory Manual is an essential guide to discovering and implementing these techniques.
    Editor
      Fritjof HelmchenBrain Research Institute, University of Zurich, Switzerland
    Publication Date2011/2011
    Bibliographic Information
    1084 pp., illus., index
    Set Info
    Topics
    Related Products Imaging in Neuroscience: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual

    Title   Imaging in Neuroscience: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imagingneurop.htm
    ISBN978-0-879699-38-3
    Price$200.00
    Series Information: 
    As imaging technologies have revolutionized research in many areas of biology and medicine, neuroscientists have often pioneered the use of new visualization techniques. Imaging in Neuroscience: A Laboratory Manual provides the definitive collection of methods in use in this groundbreaking field. With more than 90 chapters, the manual offers a depth of coverage unavailable from any other source. Sections focus on imaging at the molecular level, axons and nerve terminals, spines and dendrites, neurons and circuits in vitro, neurons and circuits in vivo, glia, brain dynamics and behavior, and brain pathology. Protocols range from basic techniques to recent breakthroughs. Imaging in Neuroscience: A Laboratory Manual is an essential guide to discovering and implementing these techniques.
    Editor
      Fritjof HelmchenBrain Research Institute, University of Zurich, Switzerland
    Publication Date2011/2011
    Bibliographic Information
    1084 pp., illus., index
    Set Info
    Topics
    Related Products Imaging in Neuroscience: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual

    Title   Imaging: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imaging.htm
    ISBN978-0-879699-35-2
    Price$246.00
    Series Information: 
    In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.
    Editor
      Rafael YusteHoward Hughes Medical Institute, Columbia University
    Publication Date2011/2011
    Bibliographic Information
    952 pp., illus. (182 color, 97 b/w), appendices, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Imaging: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual

    Title   Imaging: A Laboratory Manual
    Unique URL   http://www.cshlpress.com/link/imagingp.htm
    ISBN978-0-879699-36-9
    Price$169.00
    Series Information: 
    In recent years, imaging has rapidly become a tremendously valuable approach in nearly every field of biological research. Finding the right method and optimizing it for data collection can be a daunting process, even for an established imaging laboratory. Imaging: A Laboratory Manual is the cornerstone of a new laboratory manual series, designed as an essential guide for investigators who need these visualization techniques. This first volume is meant as a general reference for all fields, and describes the theory and practice of a wide array of imaging methods. From the basic chapters on optics, equipment and labeling to detailed explanations of advanced, cutting-edge methods like PALM, STORM, light sheet and high speed microscopy, Imaging: A Laboratory Manual is a vital resource for the modern biology laboratory.
    Editor
      Rafael YusteHoward Hughes Medical Institute, Columbia University
    Publication Date2011/2011
    Bibliographic Information
    952 pp., illus. (182 color, 97 b/w), appendices, index
    Trim size: 8-1/2” x 10-7/8”
    Set Info
    Topics
    Related Products Imaging: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Developmental Biology: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual
    Imaging in Neuroscience: A Laboratory Manual

    Title   Immune Tolerance
    Unique URL   http://www.cshlpress.com/link/immtol.htm
    ISBN978-0-879698-95-9
    Price$135
    Series Information: 


    Immune tolerance ensures that the immune system responds to foreign molecules and not to self-molecules. When tolerance breaks down, severe, self-destructive diseases such as rheumatoid arthritis, lupus, and multiple sclerosis may develop. Understanding the mechanisms involved in establishing and maintaining immune tolerance is essential for effectively treating these autoimmune diseases.



    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews how self-tolerant T- and B-cell populations are produced. The contributors discuss the elimination of autoreactive lymphocytes during their development in the thymus and bone marrow, the suppression of autoreactive cells by regulatory T cells in the periphery, and intrinsic mechanisms that produce clonal anergy. The roles of dendritic cells in antigen presentation and mechanisms that prevent autoreactivity in natural killer cells are also covered.



    Including discussions of autoimmune diseases, their genetic bases, and therapeutic strategies, this book is a valuable reference for all immunologists and clinicians wishing to understand or develop treatments for autoimmune diseases.



    Editor
      Diane J. MathisHarvard Medical School
    Publication Date2013/2013
    Bibliographic Information
    168 pp., illus. (2 B&W, 20 4C), index
    Set Info
    Topics

    Title   Immunity and Tolerance
    Unique URL   http://www.cshlpress.com/link/immunitytol.htm
    ISBN978-1-621820-84-0
    Price$318
    Series Information: 

    The 78th Symposium covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. Fundamental biological insights are described as well as new approaches intended to harness the immune system to treat disease, particularly cancer. The specific topics addressed in this volume include:




    • Stem cells and cell fate decisions

    • Regulation of immune cell development

    • Antigen receptor gene assembly and modification

    • Signal transduction

    • Regulation of lymphocyte function

    • Innate immune response and inflammation

    • Adaptive immunity

    • Mucosal immunity

    • Organ specific immunity

    • Immune regulation and tolerance

    • Autoimmunity and allergy

    • Immunity and cancer

    • Pathogen-immune system interactions

    • Vaccine development

    • Novel strategies to engineer/harness immunity

    Editor
      Anne O’GarraMRC National Institute of Medical Research, London, UK
    Publication Date2014/2014
    Bibliographic Information
    304 pp, illus. (65 4C, 39 B&W), Index
    Set Info
    Topics
    Related Products Immunity and Tolerance

    Title   Immunity and Tolerance
    Unique URL   http://www.cshlpress.com/link/immunitytolp.htm
    ISBN978-1-621820-85-7
    Price$129
    Series Information: 

    The 78th Symposium covers many aspects of the immune system including the genetics, biochemistry, molecular and cell biology, and developmental biology of immune responses. Fundamental biological insights are described as well as new approaches intended to harness the immune system to treat disease, particularly cancer. The specific topics addressed in this volume include:




    • Stem cells and cell fate decisions

    • Regulation of immune cell development

    • Antigen receptor gene assembly and modification

    • Signal transduction

    • Regulation of lymphocyte function

    • Innate immune response and inflammation

    • Adaptive immunity

    • Mucosal immunity

    • Organ specific immunity

    • Immune regulation and tolerance

    • Autoimmunity and allergy

    • Immunity and cancer

    • Pathogen-immune system interactions

    • Vaccine development

    • Novel strategies to engineer/harness immunity

    Editor
      Anne O’GarraMRC National Institute of Medical Research, London, UK
    Publication Date2014/2014
    Bibliographic Information
    304 pp, illus. (65 4C, 39 B&W), Index
    Set Info
    Topics
    Related Products Immunity and Tolerance

    Title   Immunoreceptor Signaling
    Unique URL   http://www.cshlpress.com/link/immrecpsig.htm
    ISBN978-0-879698-96-6
    Price$135
    Series Information: 

    The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells,
    activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structures of the T-cell and B-cell immunoreceptors,
    the numerous kinases and adaptors that associate with their intracellular tails, and the downstream signaling pathways that lead to transcription of
    interleukins and other outputs. Other contributions examine the roles of other receptors, co-stimulatory signals, and innate immune responses in regulation of immunoreceptor signaling.


    The spatial organization of the immunological synapses connecting lymphocytes and antigen-presenting cells is also discussed, along with the role
    of the cytoskeleton in immunoreceptor function. Computational models of the signaling processes complete the volume, making it essential reading for
    systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.

    Editor
      Lawrence E. SamelsonNational Institutes of Health
    Publication Date2011/2011
    Bibliographic Information
    282 pp., illus. (49 color, 7 b/w), index

    Trim size: 7” x 10”
    Set Info
    Topics

    Title   Incurable: A Life after Diagnosis
    Unique URL   http://www.cshlpress.com/link/incurable.htm
    ISBN978-1-936113-10-1
    Price$31.00
    Series Information: 
    In March 2009, during a routine medical exam, Charles Harris learned that he had incurable cancer. Although a private man, he began a blog to keep family and friends current on his progress, and found a wider audience. From the blog was born Incurable, an account of a man’s struggle to live vibrantly and with courage in the face of a fatal illness. An entrepreneur and investor by profession, Charles Harris writes about living and dying, friendship and fellowship, sports and wine, race horses and recessions. His style is optimistic, direct, humorous, and companionable. Readers will find his voice brave, inspirational, and an eloquent reminder that an understanding of cancer remains an urgent goal in biomedicine. Proceeds from this book will be used by the Harris family in support of cancer research.



    Read more about the book here.
    Author
      Charles Harris
    Publication Date2011/2011
    Bibliographic Information
    280 pp., illus.
    Set Info
    Topics

    Title   Innate Immunity & Inflammation
    Unique URL   http://www.cshlpress.com/link/innateimmun.htm
    ISBN978-1-621820-29-1
    Price$135
    Series Information: 

    The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis.


    Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check.


    The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.


    Editor
      Ruslan MedzhitovYale University School of Medicine
    Publication DateNovember 2014/2014
    Bibliographic Information
    350 pp. (approx.), illus. (41 4C), index
    Set Info
    Topics

    Title   The Inside Story: DNA to RNA to Protein
    Unique URL   http://www.cshlpress.com/link/inside.htm
    ISBN978-087969750-1
    Price$29
    Series Information: 
    A collection of reprinted articles from the review journal Trends in Biochemical Sciences (TiBS) focusing on the central dogma of molecular biology—DNA makes RNA makes protein. The biographical and autobiographical articles graphically describe the great discoveries in the field from an insider's perspective.
    Editor
      Jan WitkowskiCold Spring Harbor Laboratory
    Publication Date2005/2005
    Bibliographic Information
    382 pp., illus., index
    Set Info
    Topics

    Title   Inspiring Science: Jim Watson and the Age of DNA
    Unique URL   http://www.cshlpress.com/link/insp.htm
    ISBN978-087969698-6
    Price$37
    Series Information: 

    For James D. Watson, the year 2003 was momentous: The 50th anniversary of the discovery, with Francis Crick, of the DNA double helix&#059; the 35th anniversary of the publication of his best–selling memoir of the discovery, The Double Helix&#059; the 35th anniversary of his appointment as Director of Cold Spring Harbor Laboratory, an institution he molded into a research and education center of international renown and prestige: and the year in which the sequencing of the human genome was completed, a project of unprecedented international effort and coordination that Watson got off the ground and sustained during its first, critical years.


    In the course of his 75 years, Watson has achieved a reputation as outspoken, capricious, abrasive, and ruthless in pursuing his visionary goals. Few other scientists have achieved his celebrity status, or enjoyed it so much, without losing professional credibility.


    Yet behind the public notoriety there is a complexity apparent only to those who know Watson as a colleague, mentor, inspiration, and friend. This book gives voice to 43 of these individuals—people of distinction who have worked with Watson as a scientist, educator, author, administrator, and government official.


    Their essays cover much of his scientific life and, taken together, create a portrait of a complex man whose originality and force of will have produced extraordinary achievements.

    Editor
      John InglisCold Spring Harbor Laboratory
    Publication Date2003/2003
    Bibliographic Information
    503 pp., illus., bibliography, index
    Set Info
    Topics

    Title   Intellectual Property in Molecular Medicine
    Unique URL   http://www.cshlpress.com/link/intelprop.htm
    ISBN978-1-621820-83-3
    Price$135
    Series Information: 

    As universities increasingly spin off biotech companies and academics work more closely with these companies and the pharma industry, it is essential that they gain an understanding of intellectual property law and patenting. This book introduces the basic ideas and discusses how they apply to biomedical research and product development in the age of genomics.


    Editor
      Salim MamajiwallaIn(sci)te IP Inc.
    Publication DateJanuary 2015/2014
    Bibliographic Information
    350 pp. (approx.), illus., index
    Set Info
    Topics

    Title   Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics
    Unique URL   http://www.cshlpress.com/link/introprotdnap.htm
    ISBN978-1-936113-50-7
    Price$45
    Series Information: 
    One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.















    Figs 3-4, 3-5, 3-6, 3-7, and 3-8 from Chapter 3


    Click on the small images for a larger view.




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-4




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-5




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-6





    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-7




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-8


    ©2012 Cold Spring Harbor Laboratory Press

    Author
      Gary D. Stormo, Ph.D.
    Publication Date2013/2013
    Bibliographic Information
    208 pp., illus. (78 4C, 5 B&W), index
    Set Info
    Topics

    Title   Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics
    Unique URL   http://www.cshlpress.com/link/introprotdna.htm
    ISBN978-1-936113-49-1
    Price$79
    Series Information: 
    One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.















    Figs 3-4, 3-5, 3-6, 3-7, and 3-8 from Chapter 3


    Click on the small images for a larger view.




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-4




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-5




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-6





    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-7




    Introduction to Protein–DNA Interactions figure:4 thumbnail image


    Figure: 3-8


    ©2012 Cold Spring Harbor Laboratory Press

    Author
      Gary D. Stormo, Ph.D.
    Publication Date2013/2013
    Bibliographic Information
    208 pp., illus. (78 4C, 5 B&W), index
    Set Info
    Topics

    Title   Invertebrate Neurobiology
    Unique URL   http://www.cshlpress.com/link/invrtneur.htm
    ISBN978-087969819-5
    Price$135
    Series Information: 

    This collection from Cold Spring Harbor Perspectives in Biology captures the current excitement in invertebrate neurobiology, from the manipulation of activity in specified neurons to the investigation of behavior. The monograph emphasizes the evolutionary aspects of neurobiology and work on non-model species. The chapters, from internationally respected contributors, incorporate trenchant findings but also identify important outstanding questions. The volume will inspire graduate students and post-docs, and provide a good starting point for any scientist who wants to learn about this resurgent field.



    To read Geoffrey North's Foreword, click here.

    Editor
      Geoffrey NorthEditor of Current Biology
    Publication Date2007/2007
    Bibliographic Information
    665 pp., illus., index
    Set Info
    Topics
    Related Products An Introduction to Nervous Systems
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    Drosophila Neurobiology: A Laboratory Manual
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    Title   Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family
    Unique URL   http://www.cshlpress.com/link/ingenesp.htm
    ISBN978-087969721-1
    Price$21
    Series Information: 
    It is now clear that our risk of developing almost any disease is influenced by the genes with which we are born. One of the most important dividends of the Human Genome Project will be a much greater understanding of the influence of genes on disease and disorders in children (from asthma to autism) and adults (including heart disease, virtually all cancers, and Alzheimer's disease). The nature of genetic risks in families is becoming clearer and this book is written to help people understand them. Philip Reilly, a physician–geneticist, who has given hundreds of lectures on this subject, takes a user–friendly approach. Drawing on the many questions he has been asked (for example, “My sister has multiple sclerosis. Am I at an increased risk?”), Reilly discusses over 90 common conditions, diseases, and disorders, arranged from conception to old age. In frank, non–technical terms, he makes clear what is known and not known about the genetic factors and, if your risk is elevated, what you might be able to do about it. This book is a uniquely valuable resource for anyone seeking more information about a family’s disease heritage.
    Author
      Philip R. ReillyInterleukin Genetics
    Publication Date2004/2004
    Bibliographic Information
    304 pp., tables, further reading, index
    Set Info
    Topics
    Related Products Is It in Your Genes? The Influence of Genes on Common Disorders and Diseases that Affect You and Your Family
    The Strongest Boy in the World: How Genetic Information is Reshaping Our Lives
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    Title   Genes & Development
    Unique URL   http://www.cshlpress.com/link/genesdev.htm
    ISBN1
    Price$
    Journal Subscription
    Series Information: 


    Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
    This journal is published in association with The Genetical Society of Great Britain.
    Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

    Editor
      T. GrodzickerCold Spring Harbor Laboratory Press
    Publication Date/2015
    Bibliographic Information
    ISSN 0890-9369; Volume 29 includes full online access
    FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
    Set Info
    Topics

    Title   Genome Research
    Unique URL   http://www.cshlpress.com/link/genome.htm
    ISBN2
    Price$
    Journal Subscription
    Series Information: 
    In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

    Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

    New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

    Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).
    Editor
      Hillary SussmanCold Spring Harbor Laboratory Press
    Publication Date/2015
    Bibliographic Information
    ISSN: 1088-9051; Volume 25 includes full online access
    FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
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    Learning & Memory
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    Title   Learning & Memory
    Unique URL   http://www.cshlpress.com/link/learnmem.htm
    ISBN3
    Price$
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    Learning & Memory is the journal of choice for interdisciplinary studies on synaptic plasticity, learning, and memory. Until now, there has been no one journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Spanning molecules, cells, systems, and behavior, L&M considers research using approaches from cellular and molecular biology, genetics, biochemistry, computational neuroscience, neurophysiology, neuropharmacology, neuroanatomy, behavior, and cognition. Learning & Memory provides a forum for these investigations in the form of original research papers, review articles, and brief communications.
    Editor
      John H. ByrneUniversity of Texas School of Medicine
    Publication Date/2015
    Bibliographic Information
    ISSN 1549-5485; Volume 22; includes full online access
    FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
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    Genome Research
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    Title   CSH Perspectives in Medicine
    Unique URL   not available
    ISBN7
    Price$
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    Series Information: 


    Cold Spring Harbor Perspectives in Medicine is a new online publication covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Each issue offers reviews on different aspects of a variety of diseases and the tissues they affect. The contributions are written by experts in each field and commissioned as Subject Collections by a board of eminent scientists and physicians, all of whom are acknowledged to be key figures in their particular fields. These Subject Collections gradually accumulate articles as new issues of the journal are published and, when complete, each represents a comprehensive survey of the field it covers. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine. 




    Cold Spring Harbor Perspectives in Medicine is freely available until 2013.



    Please visit www.perspectivesinmedicine.org for complete information about the journal.



    Subject Coverage includes:



    • Addiction

    • Aging

    • Alzheimer Disease

    • Anemia

    • Antibiotic Resistance

    • Bacterial Pathogens

    • Bone Disease

    • Cancer

    • Cystic Fibrosis

    • Diabetes

    • Heart Disease

    • Hemoglobin

    • HIV

    • Influenza

    • Malaria

    • Multiple Sclerosis

    • Muscular Dystrophy

    • Parkinson's Disease

    • Prion Diseases

    • Skin Diseases

    • Schizophrenia


    Publication Date/2015
    Bibliographic Information
    ISSN: 2157-1422; Volume 5 includes full online access
    FREE ACCESS through December 2013!
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    Title   CSH Protocols
    Unique URL   not available
    ISBN5
    Price$
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    Series Information: 
    • The online source of trusted techniques in molecular and cellular biology
    • Contains new and classic protocols presented step-by-step with recipes and troubleshooting
    • Frequently updated and annotated
    • Interactive, customizable, and fully searchable


    The development of CSH Protocols is a response to requests from scientists for authoritative information about techniques with a broad editorial scope, delivered through a state-of-the-art online interface. At this site, you will find methods from Molecular Cloning along with selected protocols from many of our best-selling manuals, such as Cells and Antibodies, as well as protocols from Cold Spring Harbor’s renowned on-site courses. In addition, you will discover new cutting-edge protocols submitted by and commissioned from laboratories worldwide. A peer-reviewed online journal, CSH Protocols is updated monthly.


    Features include:

    • Step-by-step, uniformly structured formats for ease of use and printing, with clearly linked materials, cautions, recipes, and troubleshooting

    • Customizable, topic-based e-mail alerts for the latest updates in a particular field
    • Personal folders for storing favorite protocols and searches
    • Navigation tools including a specifically designed taxonomy for browsing and a variety of full-text search options
    • A kit search tool for fast access to time-saving resources
    • An online manuscript submission system for authors to contribute new protocols


    CSH Protocols — More Than Just Methods.


    Visit www.cshprotocols.org for more details on features, subscriptions, and manuscript submission.


    • Available exclusively via institutional site license
    • ISSN 1559–6095 / online, monthly


    Read within Top Institutions and Companies Such as:



    JANELIA FARM RESEARCH CAMPUS

    HARVARD UNIVERSITY

    NIH LIBRARY

    STANFORD UNIV

    MASS INST OF TECHNOLOGY

    Yale University

    MAX PLANCK INST

    CHINESE UNIV HONG KONG

    INIST-CNRS Bibliovie

    NATIONAL UNIVERSITY OF IRELAND, GALWAY

    SHOWA PHARMACEUTICAL UNIV




    Hot Topics



    • Antibodies
    • Bioinformatics / Genomics
    • Cell Biology
    • Chromatography
    • Computational Biology
    • DNA Delivery / Gene Transfer
    • Electrophoresis
    • Emerging Model Organisms
    • Genetics
    • High Throughput Analysis
    • Imaging / Microscopy
    • Immunology
    • Laboratory Organisms
    • Molecular Biology
    • Neuroscience
    • Plant Biology
    • Polymerase Chain Reaction (PCR)
    • Proteins and Proteomics
    • RNA Interference (RNAi) / siRNA
    • Stem Cells
    • Transgenic Technology

    Editor
       Richard SeverCold Spring Harbor Laboratory Press
    Publication Date/2015
    Bibliographic Information
    ISSN: 1559-6095; Volume 10; includes full online access
    FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
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    Title   CSH Perspectives in Biology
    Unique URL   not available
    ISBN6
    Price$
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    Series Information: 

    A new online publication for the molecular life sciences



    Cold Spring Harbor Perspectives in Biology provides the scientific community with comprehensive, systematic surveys of topics in the molecular life sciences where research is breaking new ground


    In July 2009, Cold Spring Harbor Laboratory Press launched a new monthly journal, Cold Spring Harbor Perspectives in Biology, that provides comprehensive, systematically structured surveys of research in exciting areas of molecular and cellular biology, genetics, developmental biology, neuroscience, cancer biology, and molecular pathology.


    For decades, Cold Spring Harbor Laboratory has complemented its groundbreaking research with publication of a variety of highly prestigious titles written and edited by leading scientists. These include the journals Genes & Development and Genome Research, the ‘bible’ of research methods, Molecular Cloning, online teaching resources, and numerous other laboratory manuals, monographs, handbooks, journals, and textbooks.


    Cold Spring Harbor Perspectives in Biology (http://www.cshperspectives.org; ISSN 1943-0264) is the latest, and perhaps most ambitious, addition to this stable. Its depth of coverage is unmatched, spanning the entire spectrum of the molecular life sciences and therefore providing an essential resource for all areas of bioscience research.


    According to the journal’s Executive Editor, Richard Sever, who has worked on traditional review journals including the Current Opinion and Trends titles, Cold Spring Harbor Perspectives in Biology has a new and unique approach. “There are many review articles published each year, but they’re usually on one particular aspect of one particular field,” he says. "CSH Perspectives is different. We cover subjects by asking experts to consider how best to structure a comprehensive survey of their field, and then commission articles from all the key figures in that field. And we cover everything in bioscience from Alzheimer’s to plant biology."


    CSH Perspectives articles are all commissioned as ‘collections’ by a board of eminent academic editors and gradually accumulate online at the journal’s website each month as they are accepted and published. The debut issue features articles commissioned by Elaine Fuchs, Michael Karin, W. James Nelson, and Peter Lawrence and includes contributions from Nobel laureate David Baltimore, molecular motor expert Nobutaka Hirokawa, and developmental biologist Jim Smith. These set the stage for subject collections on symmetry breaking, morphogen gradients, cell junctions, and the immune signaling molecule NF-kB. Next in the pipeline are articles on the origin of life, the p53-family of tumor suppressors, the nucleus, and immune tolerance.


    The new publication is produced online in partnership with Stanford University Library’s HighWire Press, taking advantage of their new H20 platform. The state-of-the-art website includes HTML and PDF views, high-resolution artwork, and video material, along with a host of novel features such as author updates, commenting options, and Twitter-powered news feeds.





    Publication Date/2015
    Bibliographic Information
    ISSN: 1943-0264; Volume 7 includes full online access
    FREE TRIAL ACCESS offer for libraries! Contact
    cironek@cshl.edu.
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    Title   RNA
    Unique URL   http://www.cshlpress.com/link/rna.htm
    ISBN4
    Price$
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    Series Information: 
    RNA, the publication of the RNA Society, publishes high quality research papers that provide significant new insight into any area of RNA biology, including molecular biology, cell biology, biochemistry, bioinformatics, genetics and evolution. RNA publishes two research formats, articles and short reports. In addition, the journal publishes novel methodologies, reviews and perspectives. RNA provides a unique resource to all members of the RNA community and those that wish to keep abreast of this quickly moving area.
    Editor
      Timothy W. Nilsen, Editor-in-ChiefCase Western Reserve University
    Publication Date/2015
    Bibliographic Information
    ISSN 1355-8382; Volume 21; includes full online access.
    FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
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    Related Products Genes & Development
    Genome Research
    Learning & Memory

    Title   Lab Dynamics: Management and Leadership Skills for Scientists, Second Edition
    Unique URL   http://www.cshlpress.com/link/labdyn2.htm
    ISBN978-1-936113-78-1
    Price$59
    Series Information: 

    Lab Dynamics is a unique guide to the interpersonal side of scientific research and management. The book provides practical solutions to some of the toughest problems that working scientists and science managers face daily – problems for which most scientists are unprepared. Eleven thematically focused chapters show scientists how to communicate and interact more productively and how to develop and improve their management and leadership skills.


    Every chapter from the first edition has been revised, updated and supplemented with new illustrations and graphics; many new case studies have been added to illustrate themes and techniques.


    Two new chapters have been added and new sections have been added to Chapter 3, “Gordian Knots: Solve the Toughest Problems through Negotiation” and Chapter 7 “Win/Win with Peers: Make Allies, Not Enemies”, which now contains a section on Dealing with Difficult People.


    Click here to read the Nature review of CSHL’s ‘Workshop on Leadership in BioScience’.

    Author
      Carl M. CohenScience Management Associates, Newton, Massachusetts
    Publication Date2012/2012
    Bibliographic Information
    280 pp., illus., index
    Set Info
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    Title   Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition
    Unique URL   http://www.cshlpress.com/link/labmath2.htm
    ISBN978-1-936113-71-2
    Price$59
    Series Information: 

    Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition, collects in one place the numbers and equations you rely on for your experiments and use to report your data—what they mean and how to use them—as well as easy-to-follow shortcuts for making the math easier. Written in an accessible and informal style, Lab Math describes basic mathematical principles and various tasks involving numbers, including how to calibrate lab equipment, how to make solutions, and the numbers involved in various methods for quantifying DNA, RNA, and proteins, and an all-new section on quantitative polymerase chain reaction. Basic statistical ideas and methods and the proper reporting of uncertainty are described in simple-to-understand language. Also included are reference tables, charts and “plug-and-chug” equation blanks for specific experimental procedures. Since the publication of the first edition in 2003, Lab Math has become an essential math reference and teaching resource for both on-the-spot practical information and background for understanding numerical tasks. Important additions in this second edition make Lab Math an even more useful tool for every laboratory.


    Author
      Dany Spencer AdamsThe Tufts Center for Regenerative and Developmental Biology and Department of Biology, Tufts University
    Publication Date2014/2014
    Bibliographic Information
    332 pp., illus. (49 B&W), index
    Set Info
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    Title   Lab Ref, Volume 1
    A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench

    Unique URL   http://www.cshlpress.com/link/labrefp.htm
    ISBN978-1-936113-79-8
    Price$25
    Series Information: 

    This handbook of valuable information extracted from laboratory manuals published by Cold Spring Harbor Laboratory Press is presented in an easy-to-use format. It contains invaluable reference data, never before assembled in one handy package. It has been assembled from extensively field-tested manuals, ensuring accuracy and reliability, by two scientists with extensive and diverse experience of laboratory practice.

    Editor
      Jane RoskamsUniversity of British Columbia, Canada
    Publication Date2002/2002
    Bibliographic Information
    272 pp., illus., appendices, index
    Set Info
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    Related Products Lab Ref, Volume 2
    A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench


    Title   Lab Ref, Volume 2
    A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench

    Unique URL   http://www.cshlpress.com/link/labref2.htm
    ISBN978-087969815-7
    Price$40.00
    Series Information: 
    Like its predecessor Lab Ref, Volume 1, this book is a handy benchtop source of recipes and information needed for common laboratory protocols. Lab Ref, Volume 2 contains recipes for procedures as diverse as RNA interference, imaging, proteomics, and quantitative nucleic acid analysis, and is organized by application for quick and easy reference. All recipes were derived from recent manuals published by Cold Spring Harbor Laboratory Press, and each recipe is cross-referenced to its manual of origin. Reference tables and charts are included. To meet the growing need for computational resources in the biology laboratory, Lab Ref, Volume 2 also has an expanded Web site section with sources for biological materials, databases for acquiring and annotating genomic and proteomic data, and links to downloadable software.
    Editor
      Albert S. MellickCold Spring Harbor Laboratory, New York
    Publication Date2007/2007
    Bibliographic Information
    248 pp., illus., appendix, index
    Set Info
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    Related Products Lab Ref, Volume 1
    A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench


    Title   Laboratory Research Notebook
    Unique URL   http://www.cshlpress.com/link/bsnlabp.htm
    ISBN978-087969760-0
    Price$13.95
    Series Information: 

    Cold Spring Harbor Laboratory Press presents the ultimate research notebook, the perfect tool for the student as well as the professional researcher. With 50 carbonless, duplicate pages, and table of contents, the paperback edition can help you organize the most hectic lab schedule. Each notebook includes seven pages of essential reference tables and charts, information on common solutions, and measurement conversion factors selected from Cold Spring Harbor Laboratory Press manuals. This is the most functional, economical, and professional lab resource available.

     

    Features include:

    • Pages: 50 consecutively numbered carbonless, duplicate pages

    • Page format: ¼ inch grid with signature block at the bottom

    • Table of contents for listing experiments by title, date and page number

    • Detailed instructions on keeping a laboratory notebook

    • Seven pages of tables and charts (genetic code, amino acids, solutions, buffers, periodic chart, conversion factors, etc.)

    • Laminated, water resistant soft cover, sidebound, with fold–out flap

     

     

     

     

     

    Publication Date2005/2005
    Bibliographic Information
    50 pp.
    Set Info
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    Related Products Laboratory Research Notebook
    Laboratory Research Notebook 10 Pack

    Title   Landmark Papers in Yeast Biology
    Unique URL   http://www.cshlpress.com/link/lndyeast.htm
    ISBN978-087969643-6
    Price$99
    Series Information: 
    Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD.  The papers include early, hard–to–find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature–based course on molecular cell biology.  As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that “deep study of the agreed–on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time....”
    Editor
      Patrick LinderUniversity of Geneva
    Publication Date2006/2006
    Bibliographic Information
    306 pp., index, CD
    Set Info